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    Dusp28 dual specificity phosphatase 28 [ Mus musculus (house mouse) ]

    Gene ID: 67446, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dusp28provided by MGI
    Official Full Name
    dual specificity phosphatase 28provided by MGI
    Primary source
    MGI:MGI:1914696
    See related
    Ensembl:ENSMUSG00000047067 AllianceGenome:MGI:1914696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0710001B24Rik
    Summary
    Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Orthologous to human DUSP28 (dual specificity phosphatase 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 51.0), ovary adult (RPKM 24.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 D; 1 46.6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92834711..92836342)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92906989..92908620)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glypican 1 Neighboring gene microRNA 149 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene predicted gene, 57577 Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene arginyl aminopeptidase (aminopeptidase B)-like 1 Neighboring gene STARR-seq mESC enhancer starr_01722 Neighboring gene RIKEN cDNA 9430060I03 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:94830898-94831081 Neighboring gene STARR-positive B cell enhancer ABC_E4335 Neighboring gene calpain 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity phosphatase 28
    NP_780327.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175118.3 → NP_780327.1  dual specificity phosphatase 28

      See identical proteins and their annotated locations for NP_780327.1

      Status: VALIDATED

      Source sequence(s)
      AK002934, AW493803, BE652900
      Consensus CDS
      CCDS15179.1
      UniProtKB/Swiss-Prot
      Q8BTR5
      Related
      ENSMUSP00000057690.7, ENSMUST00000060913.8
      Conserved Domains (1) summary
      cd00127
      Location:13 → 146
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      92834711..92836342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTR5.1 GenPept UniProtKB/Swiss-Prot:Q8BTR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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