Tmem178 transmembrane protein 178 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem178provided by MGI
Official Full Name: transmembrane protein 178provided by MGI
Primary source: MGI:MGI:1915277
See related: Ensembl:ENSMUSG00000024245 AllianceGenome:MGI:1915277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmem178a; 2810417M05Rik
Summary: Involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum membrane. Is expressed in cerebral cortex marginal layer; midbrain mantle layer; rest of cerebellum mantle layer; rest of cerebellum marginal layer; and ventral grey horn. Orthologous to human TMEM178A (transmembrane protein 178A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 35.6), cortex adult (RPKM 25.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E3; 17 50.97 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (81252061..81309245)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (80944632..81001816)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tmem178 Negatively Regulates IL-1beta Production Through Inhibition of the NLRP3 Inflammasome.
Title: Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome.
data identify a novel Plcgamma2/Tmem178 axis as a modulator of inflammatory cytokine production by monocytes/macrophages.
Title: Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome.
Tmem178 localizes to the ER membrane and regulates RANKL-induced Ca(2+) fluxes, thus controlling NFATc1 induction
Title: Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

D17Mit258 (e-PCR), detects polymorphism
- UniSTS:128070

G67084 (e-PCR)
- UniSTS:178293

NoName (e-PCR)
- UniSTS:487891

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 178A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.