Cst12 cystatin 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cst12provided by MGI
Official Full Name: cystatin 12provided by MGI
Primary source: MGI:MGI:1916612
See related: Ensembl:ENSMUSG00000027443 AllianceGenome:MGI:1916612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRES3; 1700006F03Rik
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in reproductive system. Orthologous to human CST12P (cystatin 12, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 58.2) and testis adult (RPKM 44.9) See more
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Genomic context

Location:: 2 G3; 2 73.55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148631285..148635352)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148789365..148793432)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cross-seeding between the functional amyloidogenic CRES and CRES3 family members and their regulation of Abeta assembly.
Title: Cross-seeding between the functional amyloidogenic CRES and CRES3 family members and their regulation of Aβ assembly.
CST12 protein may play a specialized role during spermatogenesis and sperm maturation
Title: Immunolocalization and regulation of cystatin 12 in mouse testis and epididymis.
CRES2 and CRES3 represent new members of a subgroup of cystatin family 2 proteins that likely carry out tissue-specific functions distinct from that of typical cystatins CRES2, CRES3]
Title: Cres2 and Cres3: new members of the cystatin-related epididymal spermatogenic subgroup of family 2 cystatins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cystatin-12

Names: cystatin TE-1; cystatin-related epididymal spermatogenic protein 3; cystatin-related gene expressed in testis and epididymis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027054.2 → NP_081330.2 cystatin-12 precursor

Status: VALIDATED

Source sequence(s)

AF440737, AK005670, BC119432

Consensus CDS

CCDS50737.2

UniProtKB/Swiss-Prot

Q9DAN8

UniProtKB/TrEMBL

E9Q1S9

Related

ENSMUSP00000126008.2, ENSMUST00000168443.8

Conserved Domains (1) summary

cl09238
Location:23 → 126

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.