Tcte1 t-complex-associated testis expressed 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcte1provided by MGI
Official Full Name: t-complex-associated testis expressed 1provided by MGI
Primary source: MGI:MGI:98640
See related: Ensembl:ENSMUSG00000023949 AllianceGenome:MGI:98640
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcte-1; D17Sil1
Summary: Involved in flagellated sperm motility. Located in sperm flagellum. Used to study male infertility. Orthologous to human TCTE1 (t-complex-associated-testis-expressed 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 114.1), cerebellum adult (RPKM 9.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 22.54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (45834360..45853605)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (45523434..45542679)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mouse TCTE1 is testis-enriched in its expression, with its mRNA appearing in early round spermatids and protein localized to the flagellum
Title: TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

General gene information

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Markers

D17Mit35 (e-PCR), detects polymorphism
- UniSTS:128084

fl05f06.x1 (e-PCR)
- UniSTS:201902

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynein regulatory complex subunit 5

Names: T-complex-associated testis-expressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013688.2 → NP_038716.2 dynein regulatory complex subunit 5

See identical proteins and their annotated locations for NP_038716.2

Status: VALIDATED

Source sequence(s)

AC163677, CJ047574, CX237405, M28821

Consensus CDS

CCDS37629.1

UniProtKB/Swiss-Prot

A6H639, Q62294

Related

ENSMUSP00000109175.2, ENSMUST00000113547.2

Conserved Domains (3) summary

cd00116
Location:177 → 487

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:307 → 333

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:238 → 278

LRR_AMN1; leucine-rich repeat [structural motif]