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    Ccr9 C-C motif chemokine receptor 9 [ Mus musculus (house mouse) ]

    Gene ID: 12769, updated on 12-May-2024

    Summary

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    Official Symbol
    Ccr9provided by MGI
    Official Full Name
    C-C motif chemokine receptor 9provided by MGI
    Primary source
    MGI:MGI:1341902
    See related
    Ensembl:ENSMUSG00000029530 AllianceGenome:MGI:1341902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cmkbr10; GPR-9-6; A130091K22Rik
    Summary
    Enables C-C chemokine receptor activity. Acts upstream of or within CD8-positive, gamma-delta intraepithelial T cell differentiation and chemotaxis. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; immune system; and retina. Orthologous to human CCR9 (C-C motif chemokine receptor 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward thymus adult (RPKM 118.6) See more
    Orthologs
    human all
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    Genomic context

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    See Ccr9 in Genome Data Viewer
    Location:
    9 F4; 9 74.33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123596276..123612522)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123767211..123783457)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25570 Neighboring gene leucine zipper transcription factor-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626087-123626387 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626696-123626997 Neighboring gene STARR-seq mESC enhancer starr_25571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123663531-123663880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123665948-123666172 Neighboring gene predicted gene 17021 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123693813-123694114 Neighboring gene FYVE and coiled-coil domain containing 1 Neighboring gene C-X-C motif chemokine receptor 6 Neighboring gene STARR-seq mESC enhancer starr_25572 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123760971-123761272 Neighboring gene predicted gene, 51700

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury. Koda Y, et al. JCI Insight, 2022 Sep 8. PMID 35943802, Free PMC Article
    2. Abrogation of CC Chemokine Receptor 9 Ameliorates Ventricular Electrical Remodeling in Mice After Myocardial Infarction. Huang Y, et al. Front Cardiovasc Med, 2021. PMID 34712704, Free PMC Article
    3. C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice. Amiya T, et al. Diabetologia, 2021 Mar. PMID 33399911
    4. Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction. Huang Y, et al. Sci Rep, 2016 Sep 2. PMID 27585634, Free PMC Article
    5. Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development. Evans-Marin HL, et al. PLoS One, 2015. PMID 26230654, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of chemokine receptor 9 facilitates CD4[+]CD8alphaalpha[+] intraepithelial lymphocyte development.
      Title: Downregulation of chemokine receptor 9 facilitates CD4(+)CD8αα(+) intraepithelial lymphocyte development.
    2. CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury.
      Title: CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury.
    3. Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and alpha4beta7 Integrin and Direct Their Migration In Vitro.
      Title: Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro.
    4. C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.
      Title: C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.
    5. The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation.
      Title: The Heteromeric Complex Formed by Dopamine Receptor D(5) and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation.
    6. Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis.
      Title: Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis.
    7. The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo.
      Title: The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo.
    8. Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis.
      Title: Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis.
    9. Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis.
      Title: Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis.
    10. our observations of increased circulating CCR9+ IL-17+ Treg cells and its inverse correlation with the severity of intestinal tissue injury in NEC are novel
      Title: Interleukin-6-mediated CCR9(+) interleukin-17-producing regulatory T cells polarization increases the severity of necrotizing enterocolitis.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD8-positive, gamma-delta intraepithelial T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-C chemokine receptor type 9
    Names
    C-C CKR-9
    CC-CKR-9
    CCR-9
    chemokine (C-C motif) receptor 9
    chemokine C-C receptor 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166625.1 → NP_001160097.1  C-C chemokine receptor type 9

      See identical proteins and their annotated locations for NP_001160097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC165425
      Consensus CDS
      CCDS23662.1
      UniProtKB/Swiss-Prot
      A2RSM5, Q543I4, Q9WUT7
      UniProtKB/TrEMBL
      F8WIS0
      Related
      ENSMUSP00000126758.2, ENSMUST00000168910.2
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 317
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_009913.6 → NP_034043.1  C-C chemokine receptor type 9

      See identical proteins and their annotated locations for NP_034043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC165425, AK050615
      Consensus CDS
      CCDS23662.1
      UniProtKB/Swiss-Prot
      A2RSM5, Q543I4, Q9WUT7
      UniProtKB/TrEMBL
      F8WIS0
      Related
      ENSMUSP00000127024.2, ENSMUST00000166236.9
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 317
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      123596276..123612522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUT7.1 GenPept UniProtKB/Swiss-Prot:Q9WUT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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