Pla2g2f phospholipase A2, group IIF [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g2fprovided by MGI
Official Full Name: phospholipase A2, group IIFprovided by MGI
Primary source: MGI:MGI:1349661
See related: Ensembl:ENSMUSG00000028749 AllianceGenome:MGI:1349661
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GIIFsPLA2; sPLA2-IIF
Summary: Enables phospholipase A2 activity. Involved in arachidonic acid metabolic process and phosphatidylethanolamine acyl-chain remodeling. Acts upstream of or within negative regulation of T cell proliferation and phospholipid metabolic process. Predicted to be located in extracellular region and plasma membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and urinary system. Orthologous to human PLA2G2F (phospholipase A2 group IIF). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 28.5), colon adult (RPKM 24.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138477842..138484932, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (138750533..138757598, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ethanolamine lysoplasmalogen, a PLA2G2F-derived marker product, rescued defective activation of Pla2g2f(-/-) keratinocytes both in vitro and in vivo
Title: The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
SKH2/J pigmented mice display enhanced expression of the stratum corneum acidifying enzyme, secretory phospholipase A2f (sPLA2f).
Title: Basis for enhanced barrier function of pigmented skin.
two of these isoforms, sPLA2 IIA and sPLA2 IIF, localize to the upper stratum granulosum and increase in response to experimental barrier perturbation.
Title: sPLA2 and the epidermal barrier.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

Pla2g2f (e-PCR), detects polymorphism
- UniSTS:525580

NoName (e-PCR)
- UniSTS:491377

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: group IIF secretory phospholipase A2

Names: GIIF sPLA2; phosphatidylcholine 2-acylhydrolase 2F

NP_001347804.1

EC 3.1.1.4

NP_036175.2

EC 3.1.1.4

XP_036020061.1

EC 3.1.1.4

XP_036020062.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360875.2 → NP_001347804.1 group IIF secretory phospholipase A2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1a) reflects the use of an in-frame downstream start codon for translation, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus with a predicted signal peptide, compared to isoform 1. With the available data, it is not clear which start codon is most likely used.

Source sequence(s)

AL844178

UniProtKB/Swiss-Prot

Q8CE14, Q9QZT4

Conserved Domains (1) summary

cd00125
Location:21 → 138

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
NM_012045.5 → NP_036175.2 group IIF secretory phospholipase A2 isoform 1

See identical proteins and their annotated locations for NP_036175.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes a longer protein (isoform 1), which lacks a signal peptide. With the available data, it is not clear which start codon is most likely used.

Source sequence(s)

AL844178

Consensus CDS

CCDS18832.1

UniProtKB/Swiss-Prot

Q9QZT4

Related

ENSMUSP00000030526.7, ENSMUST00000030526.7

Conserved Domains (1) summary

cd00125
Location:63 → 180

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

138477842..138484932 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164168.1 → XP_036020061.1 group IIF secretory phospholipase A2 isoform X1

Conserved Domains (1) summary

cd00125
Location:14 → 131

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_036164169.1 → XP_036020062.1 group IIF secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cl05417
Location:63 → 145

PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...