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    cfhl4 complement factor H like 4 [ Danio rerio (zebrafish) ]

    Gene ID: 559122, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cfhl4provided by ZNC
    Official Full Name
    complement factor H like 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-251
    See related
    Ensembl:ENSDARG00000102456 AllianceGenome:ZFIN:ZDB-GENE-030131-251
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cfhl2; cfhr2; im:7037131; wu:fb18c08; si:ch211-207o17.1
    Summary
    Is expressed in several structures, including digestive system; eye; fin; gill; and heart. Orthologous to human CFHR2 (complement factor H related 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See cfhl4 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (23613666..23625360, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (23587102..23598796, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene assembly factor for spindle microtubules Neighboring gene complement factor H like 5 Neighboring gene complement factor H Neighboring gene complement factor H like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish complement factor H and its related genes: identification, evolution, and expression. Sun G, et al. Funct Integr Genomics, 2010 Nov. PMID 20668901
    2. Regulator of complement activation (RCA) group 2 gene cluster in zebrafish: identification, expression, and evolution. Wu J, et al. Funct Integr Genomics, 2012 Jun. PMID 22252228
    3. Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Wang Y, et al. Funct Integr Genomics, 2011 Mar. PMID 21052758
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    complement factor H like 4
    Names
    complement factor H-related 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199366.1 → NP_001186295.1  complement factor H like 4 precursor

      See identical proteins and their annotated locations for NP_001186295.1

      Status: PROVISIONAL

      Source sequence(s)
      HM149236
      UniProtKB/TrEMBL
      E2FHP8
      Related
      ENSDARP00000138093.1, ENSDART00000163423.2
      Conserved Domains (2) summary
      cd00033
      Location:95 → 152
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:309 → 471
      PHA02927; secreted complement-binding protein; Provisional

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      23613666..23625360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296371.3 → XP_009294646.1  complement factor H like 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AMD6
      Conserved Domains (2) summary
      cd00033
      Location:123 → 180
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:337 → 499
      PHA02927; secreted complement-binding protein; Provisional

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395107.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      170428..188260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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