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    lamb2l laminin, beta 2-like [ Danio rerio (zebrafish) ]

    Gene ID: 553337, updated on 27-Mar-2024

    Summary

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    Official Symbol
    lamb2lprovided by ZNC
    Official Full Name
    laminin, beta 2-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4205
    See related
    Ensembl:ENSDARG00000033950 AllianceGenome:ZFIN:ZDB-GENE-030131-4205
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc83a09; wu:fc83a09; si:dkey-32e6.1
    Summary
    Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including basement membrane assembly; cell migration; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be part of laminin complex. Is expressed in several structures, including head; nervous system; neural tube; otic vesicle; and pronephric duct. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See lamb2l in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20262929..20338756, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20336586..20412428, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 19 Neighboring gene laminin, beta 2 (laminin S) Neighboring gene si:rp71-17i16.6 Neighboring gene si:rp71-17i16.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment. Jacoby AS, et al. Development, 2009 Oct. PMID 19736328, Free PMC Article
    2. Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Nagendran M, et al. Development, 2015 Jan 15. PMID 25519245, Free PMC Article
    3. Characterization of the laminin gene family and evolution in zebrafish. Sztal T, et al. Dev Dyn, 2011 Feb. PMID 21246659
    4. Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). Zhao N, et al. Int J Mol Sci, 2022 Sep 10. PMID 36142434, Free PMC Article
    5. Proteomics analysis of the zebrafish skeletal extracellular matrix. Kessels MY, et al. PLoS One, 2014. PMID 24608635, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in basement membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of laminin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    laminin subunit beta-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      20262929..20338756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162121.4 → XP_005162178.1  laminin subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_005162178.1

      UniProtKB/TrEMBL
      A0A8M9PDX2, F1QD37
      Conserved Domains (5) summary
      smart00180
      Location:816 → 861
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:454 → 505
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:864 → 912
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 266
      Laminin_N; Laminin N-terminal (Domain VI)
      cl25732
      Location:1243 → 1826
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_687746.9 → XP_692838.6  laminin subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_692838.6

      UniProtKB/TrEMBL
      A0A8M9PDX2, F1QD37
      Related
      ENSDARP00000048365.7, ENSDART00000048366.8
      Conserved Domains (5) summary
      smart00180
      Location:816 → 861
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:454 → 505
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:864 → 912
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 266
      Laminin_N; Laminin N-terminal (Domain VI)
      cl25732
      Location:1243 → 1826
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395143.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      92..61456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473632.1 → XP_021329307.1  laminin subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PDX2, F1QD37
      Conserved Domains (5) summary
      smart00180
      Location:816 → 861
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:454 → 505
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:864 → 912
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 266
      Laminin_N; Laminin N-terminal (Domain VI)
      cl25732
      Location:1243 → 1826
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_021473631.1 → XP_021329306.1  laminin subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PDX2, F1QD37
      Conserved Domains (5) summary
      smart00180
      Location:816 → 861
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:454 → 505
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:864 → 912
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 266
      Laminin_N; Laminin N-terminal (Domain VI)
      cl25732
      Location:1243 → 1826
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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