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    ing3 inhibitor of growth family, member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 393911, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ing3provided by ZNC
    Official Full Name
    inhibitor of growth family, member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040109-3
    See related
    Ensembl:ENSDARG00000034326 AllianceGenome:ZFIN:ZDB-GENE-040109-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56327
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization and regulation of growth. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ing3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (10604126..10615355)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (10605277..10616506)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related subfamily, member 2 Neighboring gene tetraspanin 12 Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene wingless-type MMTV integration site family, member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic analysis of the ING family of PHD finger proteins. He GH, et al. Mol Biol Evol, 2005 Jan. PMID 15356280
    2. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC56327

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200937.2 → NP_957231.1  inhibitor of growth protein 3

      See identical proteins and their annotated locations for NP_957231.1

      Status: VALIDATED

      Source sequence(s)
      AL929016, BX897748
      UniProtKB/TrEMBL
      A0A8M1PC08, Q6TEM2
      Related
      ENSDARP00000031200.5, ENSDART00000037140.7
      Conserved Domains (3) summary
      COG5034
      Location:4 → 408
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:360 → 404
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:3 → 102
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      10604126..10615355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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