rcor2 REST corepressor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rcor2provided by ZNC
Official Full Name: REST corepressor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1812
See related: Ensembl:ENSDARG00000008278 AllianceGenome:ZFIN:ZDB-GENE-040426-1812
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77264
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in brain; pectoral fin; and ventral mesoderm. Orthologous to human RCOR2 (REST corepressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24979833..24995678, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24708676..24724516, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: REST corepressor 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205638.1 → NP_991201.1 REST corepressor 2

See identical proteins and their annotated locations for NP_991201.1

Status: PROVISIONAL

Source sequence(s)

BC065331

UniProtKB/Swiss-Prot

Q6P116

Related

ENSDARP00000026854.5, ENSDART00000002961.7

Conserved Domains (4) summary

smart00717
Location:332 → 377

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:332 → 375

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:40 → 92

ELM2; ELM2 domain

cl21498
Location:128 → 172

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

24979833..24995678 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005172263.4 → XP_005172320.1 REST corepressor 2 isoform X1

See identical proteins and their annotated locations for XP_005172320.1

UniProtKB/Swiss-Prot

Q6P116

Conserved Domains (4) summary

smart00717
Location:332 → 377

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:332 → 375

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:40 → 92

ELM2; ELM2 domain

cl21498
Location:128 → 172

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_005172265.4 → XP_005172322.1 REST corepressor 2 isoform X2

See identical proteins and their annotated locations for XP_005172322.1

UniProtKB/TrEMBL

A0A8M2BJM6

Conserved Domains (4) summary

smart00717
Location:294 → 339

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:294 → 337

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:2 → 54

ELM2; ELM2 domain

cl21498
Location:90 → 134

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_005172264.3 → XP_005172321.1 REST corepressor 2 isoform X2

See identical proteins and their annotated locations for XP_005172321.1

UniProtKB/TrEMBL

A0A8M2BJM6

Conserved Domains (4) summary

smart00717
Location:294 → 339

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:294 → 337

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:2 → 54

ELM2; ELM2 domain

cl21498
Location:90 → 134

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...