Cd52 CD52 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd52provided by MGI
Official Full Name: CD52 antigenprovided by MGI
Primary source: MGI:MGI:1346088
See related: Ensembl:ENSMUSG00000000682 AllianceGenome:MGI:1346088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B7; MB7; CLS1; B7-Ag; CAMPATH-1
Summary: Acts upstream of or within response to bacterium. Located in sperm midpiece. Is expressed in embryo mesenchyme and thymus primordium. Orthologous to human CD52 (CD52 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 628.5), spleen adult (RPKM 137.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133820849..133822384, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134093538..134095073, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes.
Title: High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes.
Soluble CD52 is used by certain CD4-positive cells to suppress target celss via the inhibitory receptor Siglec-10.
Title: T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.
expression is induced in the mouse uterus at the time of embryo implantation
Title: CD52 expression is induced in the mouse uterus at the time of embryo implantation.
Study helps to precisely define CD52 expression in the tumor cell population of PTCL and might therefore be valuable when evaluating the response to alemtuzumab therapy in prospective clinical trials.
Title: CD52 expression in peripheral T-cell lymphomas determined by combined immunophenotyping using tumor cell specific T-cell receptor antibodies.
The results indicate CD52 is not required for fertilization in the mouse either in vivo or in vitro.
Title: Cd52, known as a major maturation-associated sperm membrane antigen secreted from the epididymis, is not required for fertilization in the mouse.
study examined the tissue distribution, molecular composition and immunogenicity of mouse male reproductive tract-CD52
Title: Biochemical property and immunogenicity of mouse male reproductive tract CD52 (mrt-CD52).
Genetic background determines the requirement for B7 costimulation in autoimmunity induction. Backcrossed B7.1/B7.2 deficient (-/-)mice on C57BL/6 (B6) or SJL backgrounds had different susceptibility to induced experimental autoimmune encephalomyelitis.
Title: Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (3) 1 citation

General gene information

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Markers

AI463198 (e-PCR)
- UniSTS:179085

Cd52 (e-PCR), detects polymorphism
- UniSTS:141289

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CAMPATH-1 antigen

Names: lymphocyte differentiation antigen B7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.