Pnpla7 patatin-like phospholipase domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pnpla7provided by MGI
Official Full Name: patatin-like phospholipase domain containing 7provided by MGI
Primary source: MGI:MGI:2385325
See related: Ensembl:ENSMUSG00000036833 AllianceGenome:MGI:2385325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nre; E430013P11Rik
Summary: Enables lysophospholipase activity. Involved in phosphatidylcholine catabolic process. Located in endoplasmic reticulum membrane and lipid droplet. Is expressed in several structures, including central nervous system; germ cell of testis; and retina nuclear layer. Orthologous to human PNPLA7 (patatin like phospholipase domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 14.3), liver adult (RPKM 11.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.88 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24865235..24944084)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24975990..25054072)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Title: Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism.
Title: The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism.
The Patatin-Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability.
Title: The Patatin-Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability.
The transmembrane and regulatory domain played a role in the degradation of mouse NTE-related esterase by macroautophagy and the proteasome respectively.
Title: Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.
There was a nutritional regulation of murine NTE-related esterase expression at the mRNA levels via alternative splicing.
Title: Identification of two novel splicing variants of murine NTE-related esterase.
A splice variant of the catalytic domain of mouse NRE (mNRECV) was identified in multiple adult tissues, including brain, kidney, liver and testis.
Title: Identification and characterization of a splice variant of the catalytic domain of mouse NTE-related esterase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	EXP Inferred from Experiment more info	PubMed
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: patatin-like phospholipase domain-containing protein 7

Names: NTE-related esterase; neuropathy target esterase-related esterase

NP_666363.3

EC 3.1.1.5

XP_006498077.1

EC 3.1.1.5

XP_006498078.1

EC 3.1.1.5

XP_006498079.1

EC 3.1.1.5

XP_017173518.1

EC 3.1.1.5

XP_017173519.1

EC 3.1.1.5

XP_036017642.1

EC 3.1.1.5

XP_036017643.1

EC 3.1.1.5

XP_036017644.1

EC 3.1.1.5

XP_036017645.1

EC 3.1.1.5

XP_036017646.1

EC 3.1.1.5

XP_036017648.1

EC 3.1.1.5

XP_036017652.1

EC 3.1.1.5

XP_036017653.1

EC 3.1.1.5

XP_036017654.1

EC 3.1.1.5

XP_036017655.1

EC 3.1.1.5

XP_036017656.1

EC 3.1.1.5

XP_036017658.1

EC 3.1.1.5

XP_036017659.1

EC 3.1.1.5

XP_036017660.1

EC 3.1.1.5

XP_036017661.1

EC 3.1.1.5

XP_036017662.1

EC 3.1.1.5

XP_036017664.1

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146251.4 → NP_666363.3 patatin-like phospholipase domain-containing protein 7

See identical proteins and their annotated locations for NP_666363.3

Status: VALIDATED

Source sequence(s)

AI505242, BB618610, BB852360, BC141366, BE623320

Consensus CDS

CCDS50522.1

UniProtKB/Swiss-Prot

A2AJ88, A9YTK0, B0LS74, B0ZTC6, B9EJ75, Q3TD21, Q3UFP1, Q66JS2, Q6P3F9, Q8BTY7, Q8R064, Q8R3C5

Related

ENSMUSP00000044078.8, ENSMUST00000045295.14

Conserved Domains (4) summary

cd07225
Location:933 → 1238

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

COG0664
Location:164 → 306

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:938 → 1224

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:604 → 712

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

24865235..24944084

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318029.3 → XP_017173518.1 patatin-like phospholipase domain-containing protein 7 isoform X13

UniProtKB/Swiss-Prot

A2AJ88

Conserved Domains (2) summary

cd07225
Location:907 → 1212

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:578 → 686

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161753.1 → XP_036017646.1 patatin-like phospholipase domain-containing protein 7 isoform X7

Conserved Domains (2) summary

cd07225
Location:918 → 1223

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:581 → 689

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161761.1 → XP_036017654.1 patatin-like phospholipase domain-containing protein 7 isoform X10

Conserved Domains (2) summary

cd07225
Location:915 → 1220

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:578 → 686

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161760.1 → XP_036017653.1 patatin-like phospholipase domain-containing protein 7 isoform X8

Conserved Domains (2) summary

cd07225
Location:944 → 1249

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:607 → 715

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161749.1 → XP_036017642.1 patatin-like phospholipase domain-containing protein 7 isoform X1

Conserved Domains (2) summary

cd07225
Location:944 → 1249

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:607 → 715

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161763.1 → XP_036017656.1 patatin-like phospholipase domain-containing protein 7 isoform X12

Conserved Domains (2) summary

cd07225
Location:944 → 1249

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:607 → 715

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161752.1 → XP_036017645.1 patatin-like phospholipase domain-containing protein 7 isoform X6

Conserved Domains (2) summary

cd07225
Location:944 → 1249

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:607 → 715

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_006498014.5 → XP_006498077.1 patatin-like phospholipase domain-containing protein 7 isoform X4

Conserved Domains (2) summary

cd07225
Location:936 → 1241

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:607 → 715

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_006498016.5 → XP_006498079.1 patatin-like phospholipase domain-containing protein 7 isoform X9

Conserved Domains (2) summary

cd07225
Location:936 → 1241

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:607 → 715

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161751.1 → XP_036017644.1 patatin-like phospholipase domain-containing protein 7 isoform X3

Conserved Domains (2) summary

cd07225
Location:941 → 1246

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:604 → 712

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_006498015.5 → XP_006498078.1 patatin-like phospholipase domain-containing protein 7 isoform X5

Conserved Domains (2) summary

cd07225
Location:933 → 1238

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:604 → 712

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_017318030.3 → XP_017173519.1 patatin-like phospholipase domain-containing protein 7 isoform X14

UniProtKB/Swiss-Prot

A2AJ88

Conserved Domains (2) summary

cd07225
Location:933 → 1238

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:604 → 712

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161765.1 → XP_036017658.1 patatin-like phospholipase domain-containing protein 7 isoform X15

Conserved Domains (2) summary

cd07225
Location:863 → 1168

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:526 → 634

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161766.1 → XP_036017659.1 patatin-like phospholipase domain-containing protein 7 isoform X16

Conserved Domains (2) summary

cd07225
Location:860 → 1165

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:523 → 631

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161755.1 → XP_036017648.1 patatin-like phospholipase domain-containing protein 7 isoform X7

Conserved Domains (2) summary

cd07225
Location:918 → 1223

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:581 → 689

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161759.1 → XP_036017652.1 patatin-like phospholipase domain-containing protein 7 isoform X7

Conserved Domains (2) summary

cd07225
Location:918 → 1223

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:581 → 689

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161767.1 → XP_036017660.1 patatin-like phospholipase domain-containing protein 7 isoform X17

Conserved Domains (2) summary

cd07225
Location:852 → 1157

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:523 → 631

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161769.1 → XP_036017662.1 patatin-like phospholipase domain-containing protein 7 isoform X19

Conserved Domains (2) summary

cd07225
Location:639 → 944

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:310 → 418

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161771.1 → XP_036017664.1 patatin-like phospholipase domain-containing protein 7 isoform X19

Conserved Domains (2) summary

cd07225
Location:639 → 944

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:310 → 418

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161762.1 → XP_036017655.1 patatin-like phospholipase domain-containing protein 7 isoform X11

Conserved Domains (2) summary

cd07225
Location:907 → 1212

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:578 → 686

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161750.1 → XP_036017643.1 patatin-like phospholipase domain-containing protein 7 isoform X2

Conserved Domains (2) summary

cd07225
Location:942 → 1247

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:605 → 713

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036161768.1 → XP_036017661.1 patatin-like phospholipase domain-containing protein 7 isoform X18

Conserved Domains (2) summary

cd07225
Location:647 → 952

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:310 → 418

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...