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    Npsr1 neuropeptide S receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 319239, updated on 8-May-2024

    Summary

    Official Symbol
    Npsr1provided by MGI
    Official Full Name
    neuropeptide S receptor 1provided by MGI
    Primary source
    MGI:MGI:2441738
    See related
    Ensembl:ENSMUSG00000043659 AllianceGenome:MGI:2441738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GPRA; MVTR; VRR1; PGR14; Gpr154; 9330128H10Rik
    Summary
    Predicted to enable neuropeptide receptor activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of release of sequestered calcium ion into cytosol; and righting reflex. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in asthma; inflammatory bowel disease; newborn respiratory distress syndrome; and rheumatoid arthritis. Orthologous to human NPSR1 (neuropeptide S receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Npsr1 in Genome Data Viewer
    Location:
    9 A3- A4; 9 9.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (24009212..24229151)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (24097912..24317590)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23577 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene stromal membrane-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23578 Neighboring gene STARR-seq mESC enhancer starr_23579 Neighboring gene STARR-seq mESC enhancer starr_23580 Neighboring gene STARR-seq mESC enhancer starr_23583 Neighboring gene predicted gene 10701 Neighboring gene predicted gene, 22380 Neighboring gene dpy-19 like C-mannosyltransferase 1 Neighboring gene predicted gene, 57533

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables vasopressin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuropeptide S receptor
    Names
    G protein-coupled receptor 154
    G protein-coupled receptor PGR14
    vasotocin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175678.3NP_783609.1  neuropeptide S receptor

      See identical proteins and their annotated locations for NP_783609.1

      Status: VALIDATED

      Source sequence(s)
      AK033957
      Consensus CDS
      CCDS22930.1
      UniProtKB/Swiss-Prot
      Q80T64, Q8BYA1, Q8BZP8
      UniProtKB/TrEMBL
      A1KXK3
      Related
      ENSMUSP00000056432.5, ENSMUST00000059650.11
      Conserved Domains (1) summary
      cd15197
      Location:50341
      7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      24009212..24229151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313417.3XP_017168906.1  neuropeptide S receptor isoform X1

      UniProtKB/Swiss-Prot
      Q80T64, Q8BYA1, Q8BZP8
      UniProtKB/TrEMBL
      A1KXK3
      Conserved Domains (1) summary
      cd15197
      Location:50341
      7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_036155047.1XP_036010940.1  neuropeptide S receptor isoform X1

      UniProtKB/Swiss-Prot
      Q80T64, Q8BYA1, Q8BZP8
      UniProtKB/TrEMBL
      A1KXK3
      Conserved Domains (1) summary
      cd15197
      Location:50341
      7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_017313418.2XP_017168907.1  neuropeptide S receptor isoform X2

      UniProtKB/TrEMBL
      A6X922
      Related
      ENSMUSP00000115126.2, ENSMUST00000154644.2
      Conserved Domains (2) summary
      cd14964
      Location:930
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1188
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily