Trerf1 transcriptional regulating factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trerf1provided by MGI
Official Full Name: transcriptional regulating factor 1provided by MGI
Primary source: MGI:MGI:2442086
See related: Ensembl:ENSMUSG00000064043 AllianceGenome:MGI:2442086
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAPA; Trep132; Trep-132; B830015H24; 9430096I18Rik
Summary: Predicted to enable several functions, including nuclear receptor coactivator activity; progesterone receptor binding activity; and transcription coactivator binding activity. Predicted to be involved in cellular response to steroid hormone stimulus; histone deacetylation; and regulation of transcription, DNA-templated. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut; and hemolymphoid system. Orthologous to human TRERF1 (transcriptional regulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 13.0), thymus adult (RPKM 8.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.91 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (47451868..47673250)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (47140942..47362325)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning and characterization; expression of both mTReP-132 and P450scc provides anatomical evidence that mTReP-132 may regulate this key steroidogenic enzyme within specific regions of the brain involved in behavioral and psychiatric disorders
Title: Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear progesterone receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to progesterone stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in progesterone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional-regulating factor 1

Names: transcriptional regulating protein 132; zinc finger transcription factor TReP-132

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097623.2 → NP_001091092.1 transcriptional-regulating factor 1 isoform 1

See identical proteins and their annotated locations for NP_001091092.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC112683, BC059215

UniProtKB/Swiss-Prot

Q8BXJ2

Related

ENSMUSP00000159410.2, ENSMUST00000190080.9

Conserved Domains (5) summary

smart00717
Location:914 → 959

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

sd00017
Location:1041 → 1063

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01448
Location:807 → 861

ELM2; ELM2 domain

pfam13912
Location:514 → 534

zf-C2H2_6; C2H2-type zinc finger

cl21498
Location:915 → 959

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_172622.3 → NP_766210.1 transcriptional-regulating factor 1 isoform 2

See identical proteins and their annotated locations for NP_766210.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

AC112683, AK042320, AK046822

UniProtKB/Swiss-Prot

Q32NY5, Q6PCQ4, Q80X25, Q810H8, Q8BXJ2, Q8BY31

Related

ENSMUSP00000159411.2, ENSMUST00000190020.4

Conserved Domains (5) summary

smart00717
Location:894 → 939

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

sd00017
Location:1021 → 1043

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01448
Location:787 → 841

ELM2; ELM2 domain

pfam13912
Location:514 → 534

zf-C2H2_6; C2H2-type zinc finger

cl21498
Location:895 → 939

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...