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    Lipk lipase, family member K [ Mus musculus (house mouse) ]

    Gene ID: 240633, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Lipkprovided by MGI
    Official Full Name
    lipase, family member Kprovided by MGI
    Primary source
    MGI:MGI:2679259
    See related
    Ensembl:ENSMUSG00000024771 AllianceGenome:MGI:2679259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lipl2; 9930115F20
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human LIPK (lipase family member K). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Lipk in Genome Data Viewer
    Location:
    19 C1; 19 29.3 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33985654..34025303)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34008254..34047903)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23095 Neighboring gene lipase, gastric Neighboring gene STARR-seq mESC enhancer starr_45986 Neighboring gene predicted gene, 31300 Neighboring gene lipase, family member N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC67675

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipase member K
    Names
    lipase-like abhydrolase domain-containing protein 2
    lipase-like, ab-hydrolase domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205349.1 → NP_001192278.1  lipase member K isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102119
      Consensus CDS
      CCDS57143.1
      UniProtKB/Swiss-Prot
      Q8BM14
      Related
      ENSMUSP00000053913.7, ENSMUST00000054260.8
      Conserved Domains (3) summary
      pfam00561
      Location:83 → 382
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:40 → 101
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:82 → 210
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_172837.4 → NP_766425.1  lipase member K isoform 2 precursor

      See identical proteins and their annotated locations for NP_766425.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC102119, AK037106, BY150606
      Consensus CDS
      CCDS89381.1
      UniProtKB/Swiss-Prot
      Q7TML7, Q8BM14
      Related
      ENSMUSP00000152955.2, ENSMUST00000225505.2
      Conserved Domains (3) summary
      pfam00561
      Location:78 → 377
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:34 → 96
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:77 → 205
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      33985654..34025303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM14.1 GenPept UniProtKB/Swiss-Prot:Q8BM14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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