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    Ptprh protein tyrosine phosphatase receptor type H [ Mus musculus (house mouse) ]

    Gene ID: 545902, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ptprhprovided by MGI
    Official Full Name
    protein tyrosine phosphatase receptor type Hprovided by MGI
    Primary source
    MGI:MGI:3026877
    See related
    Ensembl:ENSMUSG00000035429 AllianceGenome:MGI:3026877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sap-1; R-PTP-H
    Summary
    Predicted to enable cadherin binding activity and protein tyrosine phosphatase activity. Involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Located in microvillus. Is expressed in intestine; stomach; and testis. Orthologous to human PTPRH (protein tyrosine phosphatase receptor type H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 59.8), small intestine adult (RPKM 50.8) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptprh in Genome Data Viewer
    Location:
    7 A1; 7 2.63 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4551607..4607040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4548608..4604041, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3 Neighboring gene synaptotagmin V Neighboring gene hematological and neurological expressed 1-like pseudogene Neighboring gene predicted gene 9463

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a Role in Regulating the Intestinal Paracellular Transport of Macromolecules. Mori S, et al. J Pharm Sci, 2017 Sep. PMID 28431964
    2. Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium. Murata Y, et al. Proc Natl Acad Sci U S A, 2015 Aug 4. PMID 26195794, Free PMC Article
    3. Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Murata Y, et al. Genes Cells, 2010 May. PMID 20398064
    4. SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Sadakata H, et al. Genes Cells, 2009 Mar. PMID 19170756
    5. The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. Shintani T, et al. J Biochem, 2015 Sep. PMID 26063811

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results of this study suggest the partial contribution of SAP-1 to the regulated transport of hydrophilic macromolecules through paracellular tight junctions.
      Title: Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a Role in Regulating the Intestinal Paracellular Transport of Macromolecules.
    2. SAP-1 and CEACAM20 thus constitute a regulatory system through which the intestinal epithelium contributes to intestinal immunity.
      Title: Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
    3. These results thus suggest that SAP-1 is a microvillus-specific receptor-type protein tyrosine phosphatase that regulates intestinal tumorigenesis.
      Title: SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase H
    Names
    receptor type protein tyrosine phosphatase sap-1
    stomach cancer-associated protein tyrosine phosphatase 1
    NP_997153.2
    XP_006540267.1
    XP_011248936.1
    XP_011248937.1
    XP_011248938.1
    XP_011248939.1
    XP_011248940.1
    XP_011248941.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207270.3 → NP_997153.2  receptor-type tyrosine-protein phosphatase H precursor

      Status: VALIDATED

      Source sequence(s)
      AC161197, AC161218
      Consensus CDS
      CCDS51974.1
      UniProtKB/Swiss-Prot
      B6ZDS3, E9Q0N2, Q8BIW7
      Related
      ENSMUSP00000125833.2, ENSMUST00000166650.3
      Conserved Domains (4) summary
      smart00060
      Location:156 → 234
      FN3; Fibronectin type 3 domain
      smart00194
      Location:670 → 929
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:698 → 928
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:67 → 146
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4551607..4607040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250634.3 → XP_011248936.1  receptor-type tyrosine-protein phosphatase H isoform X1

      Conserved Domains (3) summary
      smart00060
      Location:334 → 412
      FN3; Fibronectin type 3 domain
      cd00063
      Location:67 → 146
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl28904
      Location:881 → 1113
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_006540204.4 → XP_006540267.1  receptor-type tyrosine-protein phosphatase H isoform X6

      Conserved Domains (3) summary
      smart00060
      Location:518 → 594
      FN3; Fibronectin type 3 domain
      cd00063
      Location:67 → 146
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl28904
      Location:788 → 1020
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_011250635.3 → XP_011248937.1  receptor-type tyrosine-protein phosphatase H isoform X2

      Conserved Domains (3) summary
      smart00060
      Location:334 → 412
      FN3; Fibronectin type 3 domain
      cd00063
      Location:67 → 146
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl28904
      Location:877 → 1109
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_011250639.3 → XP_011248941.1  receptor-type tyrosine-protein phosphatase H isoform X7

      Conserved Domains (3) summary
      smart00060
      Location:334 → 412
      FN3; Fibronectin type 3 domain
      cd00063
      Location:67 → 146
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl28904
      Location:788 → 1020
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_011250636.3 → XP_011248938.1  receptor-type tyrosine-protein phosphatase H isoform X3

      Conserved Domains (3) summary
      smart00060
      Location:334 → 412
      FN3; Fibronectin type 3 domain
      cd00063
      Location:67 → 146
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl28904
      Location:877 → 1109
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_011250638.3 → XP_011248940.1  receptor-type tyrosine-protein phosphatase H isoform X5

      Conserved Domains (3) summary
      smart00060
      Location:334 → 412
      FN3; Fibronectin type 3 domain
      cd00063
      Location:67 → 146
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl28904
      Location:792 → 1024
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_011250637.3 → XP_011248939.1  receptor-type tyrosine-protein phosphatase H isoform X4

      Conserved Domains (3) summary
      smart00060
      Location:288 → 366
      FN3; Fibronectin type 3 domain
      cd00063
      Location:21 → 100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl28904
      Location:835 → 1067
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_003946524.1 RNA Sequence

    2. XR_881746.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q0N2.1 GenPept UniProtKB/Swiss-Prot:E9Q0N2

    Gene LinkOut

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