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    Gngt2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [ Mus musculus (house mouse) ]

    Gene ID: 14710, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Gngt2provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2provided by MGI
    Primary source
    MGI:MGI:893584
    See related
    Ensembl:ENSMUSG00000038811 AllianceGenome:MGI:893584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3i
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in retina outer nuclear layer and thymus primordium. Orthologous to human GNGT2 (G protein subunit gamma transducin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 5.4), lung adult (RPKM 5.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gngt2 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95733045..95736557)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95841772..95845734)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38958 Neighboring gene phosphatase, orphan 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95694502-95694744 Neighboring gene ABI family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95695557-95695835 Neighboring gene predicted gene, 38959 Neighboring gene RIKEN cDNA 4833417C18 gene Neighboring gene STARR-positive B cell enhancer ABC_E305 Neighboring gene nuclear encoded tRNA glutamine 6 (anticodon TTG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways. Ibanez KR, et al. Alzheimers Res Ther, 2022 Jul 27. PMID 35897046, Free PMC Article
    2. Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. Rich KA, et al. J Comp Neurol, 1997 Nov 10. PMID 9364238
    3. The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Rodgers HM, et al. Mech Dev, 2018 Jun. PMID 29665410, Free PMC Article
    4. Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development. Fujieda H, et al. J Neurochem, 2009 Jan. PMID 19014374
    5. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Abi3/Gngt2 influences age-progressive amyloid beta and tau pathologies in distinctive ways.
      Title: Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
    Names
    G-gamma-8
    g gamma-C
    guanine nucleotide binding protein (G protein), gamma transducing polypeptide 2
    heterotrimeric guanine nucleotide-binding protein 3i

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038664.2 → NP_001033753.2  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

      See identical proteins and their annotated locations for NP_001033753.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AA028742, BC061005, W35863
      Consensus CDS
      CCDS25284.1
      UniProtKB/Swiss-Prot
      Q61017, Q9CWL5
      UniProtKB/TrEMBL
      A2A614, Q6P8Y9
      Related
      ENSMUSP00000098101.4, ENSMUST00000100532.10
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    2. NM_001284393.1 → NP_001271322.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

      See identical proteins and their annotated locations for NP_001271322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      BC061005, BE847751, BY117112
      Consensus CDS
      CCDS25284.1
      UniProtKB/Swiss-Prot
      Q61017, Q9CWL5
      UniProtKB/TrEMBL
      A2A614, Q6P8Y9
      Related
      ENSMUSP00000103339.2, ENSMUST00000107711.8
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    3. NM_001284397.1 → NP_001271326.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

      See identical proteins and their annotated locations for NP_001271326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' UTR exon and also lacks an internal segment in the 5' UTR, compared to variant 3. variant 3. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AA423571, AI154009, AI159118, BC061005
      Consensus CDS
      CCDS25284.1
      UniProtKB/Swiss-Prot
      Q61017, Q9CWL5
      UniProtKB/TrEMBL
      A2A614, Q6P8Y9
      Related
      ENSMUSP00000103337.2, ENSMUST00000107709.8
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    4. NM_023121.2 → NP_075610.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

      See identical proteins and their annotated locations for NP_075610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an internal segment in the 5' UTR, compared to variant 3. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL593858, BE994683, BF470980, BY117112
      Consensus CDS
      CCDS25284.1
      UniProtKB/Swiss-Prot
      Q61017, Q9CWL5
      UniProtKB/TrEMBL
      A2A614, Q6P8Y9
      Related
      ENSMUSP00000103342.3, ENSMUST00000107714.9
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95733045..95736557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532231.3 → XP_006532294.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

      See identical proteins and their annotated locations for XP_006532294.1

      UniProtKB/Swiss-Prot
      Q61017, Q9CWL5
      UniProtKB/TrEMBL
      A2A614, Q6P8Y9
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    2. XM_036156338.1 → XP_036012231.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

      UniProtKB/Swiss-Prot
      Q61017, Q9CWL5
      UniProtKB/TrEMBL
      A2A614, Q6P8Y9
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61017.2 GenPept UniProtKB/Swiss-Prot:Q61017

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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