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    Carlr cardiac and apoptosis-related long non-coding RNA [ Mus musculus (house mouse) ]

    Gene ID: 66774, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Carlrprovided by MGI
    Official Full Name
    cardiac and apoptosis-related long non-coding RNAprovided by MGI
    Primary source
    MGI:MGI:1914024
    See related
    Ensembl:ENSMUSG00000097638 AllianceGenome:MGI:1914024
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Carl; 4933439G12Rik
    Summary
    Enables pre-miRNA binding activity. Acts upstream of or within several processes, including cellular response to anoxia; negative regulation of mitochondrial fission; and regulation of miRNA metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Carlr in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18804056..18806629, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18799245..18801818, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5891 Neighboring gene sperm associated antigen 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18688736-18688845 Neighboring gene predicted gene 3363 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Neighboring gene predicted gene, 33534 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18845660-18845769 Neighboring gene RIKEN cDNA 4930426L09 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation. Wang K, et al. Nat Commun, 2014 Apr 7. PMID 24710105
    2. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CARL can suppress mitochondrial fission and apoptosis by targeting miR-539 and PHB2.
      Title: CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to anoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of miRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_131254.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK017121, AL928680, AW491495, CA319779
      Related
      ENSMUST00000181515.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      18804056..18806629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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