Cfap251 cilia and flagella associated protein 251 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cfap251provided by MGI
Official Full Name: cilia and flagella associated protein 251provided by MGI
Primary source: MGI:MGI:1918495
See related: Ensembl:ENSMUSG00000029442 AllianceGenome:MGI:1918495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr66; 5031404N07; 4930415N18Rik; 4933428F06Rik
Summary: Predicted to be involved in flagellated sperm motility. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be active in sperm flagellum. Is expressed in brain; nasal cavity respiratory epithelium; neural retina; and respiratory system. Human ortholog(s) of this gene implicated in spermatogenic failure 33. Orthologous to human CFAP251 (cilia and flagella associated protein 251). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 15.4), lung adult (RPKM 2.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.86 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (123390196..123465547)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (123251725..123327484)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wdr66 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Mit137 (e-PCR), detects polymorphism
- UniSTS:130262

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cilia- and flagella-associated protein 251

Names: WD repeat domain 66; WD repeat-containing protein 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370840.1 → NP_001357769.1 cilia- and flagella-associated protein 251

Status: VALIDATED

Source sequence(s)

AC113504, AC163337

Consensus CDS

CCDS89985.1

UniProtKB/Swiss-Prot

E9Q743, Q8BMR0, Q9D3X6

Related

ENSMUSP00000113309.2, ENSMUST00000121964.8

Conserved Domains (4) summary

PTZ00183
Location:1136 → 1239

PTZ00183; centrin; Provisional

COG2319
Location:423 → 870

WD40; WD40 repeat [General function prediction only]

sd00039
Location:658 → 688

7WD40; WD40 repeat [structural motif]

cl29593
Location:756 → 1070

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

123390196..123465547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254542.2 → XP_030110402.1 cilia- and flagella-associated protein 251 isoform X1

UniProtKB/Swiss-Prot

E9Q743, Q8BMR0, Q9D3X6

Conserved Domains (4) summary

PTZ00183
Location:1136 → 1239

PTZ00183; centrin; Provisional

COG2319
Location:423 → 870

WD40; WD40 repeat [General function prediction only]

sd00039
Location:658 → 688

7WD40; WD40 repeat [structural motif]

cl29593
Location:756 → 1070

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177760.2: Suppressed sequence

Description

NM_177760.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.