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    Bcl7a B cell CLL/lymphoma 7A [ Mus musculus (house mouse) ]

    Gene ID: 77045, updated on 9-May-2024

    Summary

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    Official Symbol
    Bcl7aprovided by MGI
    Official Full Name
    B cell CLL/lymphoma 7Aprovided by MGI
    Primary source
    MGI:MGI:1924295
    See related
    Ensembl:ENSMUSG00000029438 AllianceGenome:MGI:1924295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4432415N06Rik
    Summary
    Is expressed in several structures, including central nervous system; foregut; sensory organ; tooth; and vibrissa. Orthologous to human BCL7A (BAF chromatin remodeling complex subunit BCL7A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 21.1), CNS E11.5 (RPKM 20.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcl7a in Genome Data Viewer
    Location:
    5 F; 5 62.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123482511..123512146)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123344448..123374083)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9262 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 Neighboring gene ribosomal protein L35A, pseudogene 6 Neighboring gene cilia and flagella associated protein 251 Neighboring gene STARR-positive B cell enhancer ABC_E10350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123794689-123794872 Neighboring gene predicted gene 15860 Neighboring gene STARR-seq mESC enhancer starr_14319 Neighboring gene STARR-seq mESC enhancer starr_14320 Neighboring gene predicted gene, 23458 Neighboring gene STARR-positive B cell enhancer ABC_E2764 Neighboring gene STARR-positive B cell enhancer ABC_E8080 Neighboring gene MLX interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E3618 Neighboring gene ribosomal protein L31, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Wischhof L, et al. Sci Rep, 2017 Dec 6. PMID 29213114, Free PMC Article
    2. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Kadoch C, et al. Nat Genet, 2013 Jun. PMID 23644491, Free PMC Article
    3. BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. Wischhof L, et al. EMBO J, 2022 Dec 1. PMID 36305367, Free PMC Article
    4. m(6)A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina. Xin Y, et al. Elife, 2022 Dec 2. PMID 36459087, Free PMC Article
    5. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Gatchalian J, et al. Nat Commun, 2018 Dec 3. PMID 30510198, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
      Title: BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SWI/SNF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-cell CLL/lymphoma 7 protein family member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029850.3 → NP_084126.1  B-cell CLL/lymphoma 7 protein family member A

      See identical proteins and their annotated locations for NP_084126.1

      Status: VALIDATED

      Source sequence(s)
      AC113504, BC046777, BY271432
      Consensus CDS
      CCDS19661.1
      UniProtKB/Swiss-Prot
      Q8C361, Q8C8M8, Q8VD15, Q9CXE2
      Related
      ENSMUSP00000031391.3, ENSMUST00000031391.9
      Conserved Domains (1) summary
      pfam04714
      Location:4 → 50
      BCL_N; BCL7, N-terminal conserver region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123482511..123512146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXE2.1 GenPept UniProtKB/Swiss-Prot:Q9CXE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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