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    Wbp1 WW domain binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 22377, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wbp1provided by MGI
    Official Full Name
    WW domain binding protein 1provided by MGI
    Primary source
    MGI:MGI:104710
    See related
    Ensembl:ENSMUSG00000030035 AllianceGenome:MGI:104710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables WW domain binding activity. Orthologous to human WBP1 (WW domain binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 74.3), duodenum adult (RPKM 66.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wbp1 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83096025..83098442, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83119044..83121461, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 142 Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene STARR-positive B cell enhancer ABC_E6446 Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene STARR-positive B cell enhancer ABC_E344 Neighboring gene STARR-positive B cell enhancer ABC_E9669 Neighboring gene INO80 complex subunit B Neighboring gene rhotekin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel protein-binding module--the WW domain. Sudol M, et al. FEBS Lett, 1995 Aug 1. PMID 7641887
    2. Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands. Chen HI, et al. J Biol Chem, 1997 Jul 4. PMID 9202023
    3. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. Morishima N, et al. J Biol Chem, 2011 Oct 7. PMID 21841196, Free PMC Article
    4. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Chen HI, et al. Proc Natl Acad Sci U S A, 1995 Aug 15. PMID 7644498, Free PMC Article
    5. Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. Gavva NR, et al. J Biol Chem, 1997 Sep 26. PMID 9305852

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mcl-1 is a determinant of cell fate, and ATF6 mediates apoptosis via specific suppression of Mcl-1 through up-regulation of WBP1
      Title: Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-binding protein 1
    Names
    WBP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083922.1 → NP_001077391.1  WW domain-binding protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AI842692, AK076948, BY159385
      UniProtKB/TrEMBL
      Q8C5Y4
      Related
      ENSMUSP00000122900.2, ENSMUST00000146328.4
      Conserved Domains (1) summary
      pfam11669
      Location:70 → 176
      WBP-1; WW domain-binding protein 1

    2. NM_001083923.1 → NP_001077392.1  WW domain-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001077392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI842692, AK076948, BE860581, BY159385
      Consensus CDS
      CCDS39528.1
      UniProtKB/TrEMBL
      Q8C5Y4
      Related
      ENSMUSP00000109569.4, ENSMUST00000113936.10
      Conserved Domains (1) summary
      pfam11669
      Location:36 → 142
      WBP-1; WW domain-binding protein 1

    3. NM_016757.2 → NP_058037.2  WW domain-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_058037.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI842692, AK076948, BY159385, CX205200
      Consensus CDS
      CCDS39529.1
      UniProtKB/Swiss-Prot
      P97764, Q8WUP5, Q99J20
      UniProtKB/TrEMBL
      Q8C5Y4
      Related
      ENSMUSP00000032111.5, ENSMUST00000032111.11
      Conserved Domains (1) summary
      pfam11669
      Location:71 → 177
      WBP-1; WW domain-binding protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83096025..83098442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97764.2 GenPept UniProtKB/Swiss-Prot:P97764

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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