Muc16 mucin 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Muc16provided by MGI
Official Full Name: mucin 16provided by MGI
Primary source: MGI:MGI:1920982
See related: Ensembl:ENSMUSG00000109564 AllianceGenome:MGI:1920982
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca125; Gm1480; Gm21044; 1110008I14Rik
Summary: Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 7.06 cM

Exon count:: 89

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (18406741..18586117, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (18495445..18674821, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma.
Title: Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma.
Authors confirm that MUC16 inhibits cytolysis by human NK cells as well as the formation of NK-tumor conjugates. Mice implanted with MUC16-knockdown OVCAR-3 show >2-fold increase in survival compared to controls. Murine NK cells and macrophages are more efficient at lysing MUC16-knockdown cells.
Title: MUC16 suppresses human and murine innate immune responses.
Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
Title: Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
MAMs MUC1 and MUC16 contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses.
Title: Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16.
MUC16 functions as an oncogene. The cytoplasmic tail is critical for MUC16 oncogenic properties.
Title: Transformation of NIH3T3 mouse fibroblast cells by MUC16 mucin (CA125) is driven by its cytoplasmic tail.
Data show that intraperitoneal injections of living CA 125 positive cells of OVCAR-3 cell line, and boosted by intravenous injection of the purified extracellular domain of CA 125 was found to have excellent immunoreactivity for CA 125 mAb production.
Title: Heterologous immunization, a way out of the problem of monoclonal antibody production against carcinoma antigen 125.
Lack of any prominent abnormal phenotype in Muc16 knockout mice suggests that CA125/MUC16 is not required for normal development or reproduction
Title: CA125/MUC16 is dispensable for mouse development and reproduction.
the presence of MUC16 in murine ovarian cancer and in normal tissues
Title: MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

Muc16 (e-PCR), detects polymorphism
- UniSTS:530704

NoName (e-PCR)
- UniSTS:224290

NoName (e-PCR)
- UniSTS:224803

Muc16 (e-PCR), detects polymorphism
- UniSTS:525923

Muc16 (e-PCR), detects polymorphism
- UniSTS:525924

Muc16 (e-PCR), detects polymorphism
- UniSTS:525525

Muc16 (e-PCR), detects polymorphism
- UniSTS:525526

Muc16 (e-PCR), detects polymorphism
- UniSTS:525527

Muc16 (e-PCR), detects polymorphism
- UniSTS:525528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378248.1 → NP_001365177.1 mucin-16 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC154519, AC154784, AC162941

UniProtKB/TrEMBL

A0A140LJ72

Conserved Domains (4) summary

pfam05109
Location:4987 → 5361

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01390
Location:8618 → 8725

SEA; SEA domain

NF033849
Location:4828 → 5122

ser_rich_anae_1; serine-rich protein

cl41733
Location:8748 → 8782

Syt1_2_N; N-terminal domain of synaptotagmin-1 and -2
NM_001428752.1 → NP_001415681.1 mucin-16 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC154519, AC154784, AC162941

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

18406741..18586117 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242634.1 → XP_011240936.1 mucin-16 isoform X1

Related

ENSMUSP00000147104.2, ENSMUST00000208663.2

Conserved Domains (2) summary

pfam05109
Location:4987 → 5361

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01390
Location:6180 → 6281

SEA; SEA domain
XM_011242636.1 → XP_011240938.1 mucin-16 isoform X2

See identical proteins and their annotated locations for XP_011240938.1

UniProtKB/TrEMBL

A0A140LJ72

Conserved Domains (3) summary

pfam05109
Location:4962 → 5336

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01390
Location:6155 → 6256

SEA; SEA domain

pfam16038
Location:8734 → 8788

TMIE; TMIE protein