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    Nadk2 NAD kinase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 68646, updated on 9-May-2024

    Summary

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    Official Symbol
    Nadk2provided by MGI
    Official Full Name
    NAD kinase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1915896
    See related
    Ensembl:ENSMUSG00000022253 AllianceGenome:MGI:1915896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MNADK; Nadkd1
    Summary
    Predicted to enable NAD+ kinase activity and protein homodimerization activity. Predicted to be involved in NAD metabolic process. Located in mitochondrion. Is expressed in retina. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 40.2), liver E14.5 (RPKM 34.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nadk2 in Genome Data Viewer
    Location:
    15 A1; 15 3.82 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (9071340..9110584)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (9071260..9110496)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RAN binding protein 3-like Neighboring gene predicted gene, 53883 Neighboring gene STARR-positive B cell enhancer ABC_E1904 Neighboring gene STARR-seq mESC enhancer starr_37924 Neighboring gene STARR-positive B cell enhancer ABC_E3131 Neighboring gene S-phase kinase-associated protein 2 Neighboring gene LMBR1 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_37931 Neighboring gene STARR-seq mESC enhancer starr_37932 Neighboring gene UDP glycosyltransferases 3 family pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. Zhang K, et al. Gastroenterology, 2018 Jan. PMID 28923496, Free PMC Article
    2. [Coxsackie virus B3 (CVB3) triggers the activation of NLRP3 in mouse macrophages by activating nicotinamide adenine dinucleotide kinase 2 (NADK2)]. Sang R, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2023 Jan. PMID 36631013
    3. The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. Kim H, et al. Mol Metab, 2022 Oct. PMID 35944895, Free PMC Article
    4. Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology. Murray GC, et al. Hum Mol Genet, 2022 Nov 28. PMID 35796562, Free PMC Article
    5. MNADK, a novel liver-enriched mitochondrion-localized NAD kinase. Zhang R. Biol Open, 2013 Apr 15. PMID 23616928, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Coxsackie virus B3 (CVB3) triggers the activation of NLRP3 in mouse macrophages by activating nicotinamide adenine dinucleotide kinase 2 (NADK2)].
      Title: [Coxsackie virus B3 (CVB3) triggers the activation of NLRP3 in mouse macrophages by activating nicotinamide adenine dinucleotide kinase 2 (NADK2)].
    2. Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology.
      Title: Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology.
    3. Deleting MNADK (NADK2) in mice reduced fat oxidation upon energy demand triggered by endurance exercise or fasting. NADK2 is a major metabolic regulator upon increased energy demand.
      Title: The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand.
    4. MNADK is localized to mitochondria in Hep G2 cells, and a recombinant MNADK showed NAD kinase activity. MNADK is abundant in mitochondrion-rich tissues, such as liver. MNADK expression was suppressed in human liver tumors. Identification of MNADK immediately suggests a model in which NADK and MNADK are responsible for de novo synthesis of NADP(+) in cytosol and mitochondria, respectively.
      Title: MNADK, a novel liver-enriched mitochondrion-localized NAD kinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 1110020G09Rik, 4933430B08Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NAD kinase 2, mitochondrial
    Names
    NAD kinase domain-containing protein 1, mitochondrial
    NP_001035485.2
    NP_001078879.1
    NP_001273182.1
    NP_001273184.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040395.4 → NP_001035485.2  NAD kinase 2, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK046666, AK078318, AK162601, AW537715, BE692075, BY545448
      UniProtKB/TrEMBL
      Q14BL1
      Conserved Domains (1) summary
      cl01255
      Location:84 → 306
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. NM_001085410.2 → NP_001078879.1  NAD kinase 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001078879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK046666, AK078318, AK162601, AW537715, BE692075, BY545448
      UniProtKB/Swiss-Prot
      Q3TRP5, Q3UEY1, Q8C5H8, Q9CTE4
      UniProtKB/TrEMBL
      Q14BL1
      Related
      ENSMUSP00000159405.2, ENSMUST00000190591.10
      Conserved Domains (1) summary
      cl01255
      Location:84 → 328
      DAGK_cat; Diacylglycerol kinase catalytic domain

    3. NM_001286253.1 → NP_001273182.1  NAD kinase 2, mitochondrial isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, lacks several additional exons, and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK016988, AK046666, BF460794
      UniProtKB/TrEMBL
      A0A7P0A156
      Related
      ENSMUSP00000159408.2, ENSMUST00000190874.8
      Conserved Domains (1) summary
      cl01255
      Location:84 → 306
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. NM_001286255.1 → NP_001273184.1  NAD kinase 2, mitochondrial isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AK046666, AK078318, AK162601, AW537715, BE692075, BY545448
      UniProtKB/TrEMBL
      A0A7N9VS49
      Related
      ENSMUSP00000159407.2, ENSMUST00000189437.8
      Conserved Domains (1) summary
      cl01255
      Location:84 → 278
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      9071340..9110584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5H8.2 GenPept UniProtKB/Swiss-Prot:Q8C5H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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