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    Zfp971 zinc finger protein 971 [ Mus musculus (house mouse) ]

    Gene ID: 626848, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zfp971provided by MGI
    Official Full Name
    zinc finger protein 971provided by MGI
    Primary source
    MGI:MGI:1261426
    See related
    Ensembl:ENSMUSG00000074519 AllianceGenome:MGI:1261426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Etohi1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Orthologous to human ZNF101 (zinc finger protein 101). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.2), cerebellum adult (RPKM 2.7) and 25 other tissues See more
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    Genomic context

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    See Zfp971 in Genome Data Viewer
    Location:
    2 H4; 2 99.63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (177665077..177677652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (178023284..178035859)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06697 Neighboring gene predicted gene 14428 Neighboring gene STARR-seq mESC enhancer starr_06698 Neighboring gene STARR-positive B cell enhancer ABC_E6035 Neighboring gene STARR-positive B cell enhancer mm9_chr2:177757807-177758108 Neighboring gene predicted gene, 40030 Neighboring gene STARR-positive B cell enhancer mm9_chr2:177792959-177793260 Neighboring gene STARR-seq mESC enhancer starr_06699 Neighboring gene zinc finger protein 931 Neighboring gene phosphatase and actin regulator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Rout UK, et al. Cell Calcium, 1997 Dec. PMID 9502196
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ethanol induced 1
    Names
    KRAB box and zinc finger, C2H2 type domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177399.1 → NP_001170870.1  ethanol induced 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK005093, BX284639
      Consensus CDS
      CCDS50834.1
      UniProtKB/TrEMBL
      A2BFG8
      Related
      ENSMUSP00000104554.3, ENSMUST00000108926.3
      Conserved Domains (5) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      COG5048
      Location:75 → 458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:385 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:398 → 422
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001177400.1 → NP_001170871.1  ethanol induced 1 isoform 2

      See identical proteins and their annotated locations for NP_001170871.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the 3' exon, but has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) is C-terminal truncated, as compared to isoform 1.
      Source sequence(s)
      AK005093, U94840
      Consensus CDS
      CCDS50835.1
      UniProtKB/TrEMBL
      A2ARV8, Q3V498
      Related
      ENSMUSP00000104553.3, ENSMUST00000108925.10
      Conserved Domains (2) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 43
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      177665077..177677652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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