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    Fxyd6 FXYD domain-containing ion transport regulator 6 [ Mus musculus (house mouse) ]

    Gene ID: 59095, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fxyd6provided by MGI
    Official Full Name
    FXYD domain-containing ion transport regulator 6provided by MGI
    Primary source
    MGI:MGI:1890226
    See related
    Ensembl:ENSMUSG00000066705 AllianceGenome:MGI:1890226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Php; 0610030I18Rik
    Summary
    This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006]
    Expression
    Broad expression in CNS E18 (RPKM 180.7), whole brain E14.5 (RPKM 104.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45280768..45307457)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45369470..45396159)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene transmembrane protease, serine 13 Neighboring gene STARR-seq mESC enhancer starr_23995 Neighboring gene RIKEN cDNA 4833428L15 gene Neighboring gene predicted gene, 57798 Neighboring gene STARR-seq mESC enhancer starr_24004 Neighboring gene FXYD domain-containing ion transport regulator 2 Neighboring gene DS cell adhesion molecule like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FXYD6 is a novel regulator of Na,K-ATPase expressed in the inner ear. Delprat B, et al. J Biol Chem, 2007 Mar 9. PMID 17209044
    2. FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells. Shindo Y, et al. Biosci Biotechnol Biochem, 2011. PMID 21670532
    3. Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus. Yamaguchi F, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165386
    4. FXYD proteins: new regulators of Na-K-ATPase. Geering K. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403837
    5. Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins. Pereira Luppi M, et al. Cell Rep, 2021 Nov 9. PMID 34758317, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ion channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in presynaptic membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FXYD domain-containing ion transport regulator 6
    Names
    PLM-like protein
    phosphohippolin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022004.6 → NP_071287.1  FXYD domain-containing ion transport regulator 6 precursor

      See identical proteins and their annotated locations for NP_071287.1

      Status: REVIEWED

      Source sequence(s)
      AK003888, BG093642, BQ891313, BY081454
      Consensus CDS
      CCDS23133.1
      UniProtKB/Swiss-Prot
      Q99NC3, Q9CXD0, Q9D164
      Related
      ENSMUSP00000083101.7, ENSMUST00000085939.8
      Conserved Domains (1) summary
      cl40453
      Location:2 → 93
      FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45280768..45307457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244486.1 → XP_030100346.1  FXYD domain-containing ion transport regulator 6 isoform X1

      Conserved Domains (1) summary
      pfam02038
      Location:178 → 223
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    2. XM_036155163.1 → XP_036011056.1  FXYD domain-containing ion transport regulator 6 isoform X2

      UniProtKB/Swiss-Prot
      Q99NC3, Q9CXD0, Q9D164
      Conserved Domains (1) summary
      cl40453
      Location:2 → 93
      FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family

    3. XM_036155164.1 → XP_036011057.1  FXYD domain-containing ion transport regulator 6 isoform X2

      UniProtKB/Swiss-Prot
      Q99NC3, Q9CXD0, Q9D164
      Conserved Domains (1) summary
      cl40453
      Location:2 → 93
      FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D164.2 GenPept UniProtKB/Swiss-Prot:Q9D164

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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