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    Clasp1 CLIP associating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 76707, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Clasp1provided by MGI
    Official Full Name
    CLIP associating protein 1provided by MGI
    Primary source
    MGI:MGI:1923957
    See related
    Ensembl:ENSMUSG00000064302 AllianceGenome:MGI:1923957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLASP1alpha; 1700030C23Rik; 5730583A19Rik; B130045P17Rik
    Summary
    Enables microtubule binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in microtubule cytoskeleton. Is expressed in gastrocnemius muscle. Orthologous to human CLASP1 (cytoplasmic linker associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 33.1), whole brain E14.5 (RPKM 17.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E2.3; 1 52.14 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (118314976..118537192)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (118389058..118609462)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5790 Neighboring gene STARR-seq mESC enhancer starr_01976 Neighboring gene STARR-positive B cell enhancer mm9_chr1:120284737-120285037 Neighboring gene STARR-positive B cell enhancer mm9_chr1:120285334-120285635 Neighboring gene STARR-positive B cell enhancer mm9_chr1:120285732-120286033 Neighboring gene STARR-positive B cell enhancer ABC_E10028 Neighboring gene STARR-seq mESC enhancer starr_01978 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 Neighboring gene STARR-seq mESC enhancer starr_01979 Neighboring gene predicted gene 28867 Neighboring gene RIKEN cDNA 2900060B14 gene Neighboring gene STARR-positive B cell enhancer mm9_chr1:120355892-120356193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:120356261-120356370 Neighboring gene predicted gene, 26080 Neighboring gene STARR-seq mESC enhancer starr_01983 Neighboring gene STARR-seq mESC enhancer starr_01987 Neighboring gene STARR-seq mESC enhancer starr_01991 Neighboring gene transcription factor CP2-like 1 Neighboring gene STARR-seq mESC enhancer starr_01996 Neighboring gene predicted gene, 23497 Neighboring gene STARR-seq mESC enhancer starr_01999 Neighboring gene GLI-Kruppel family member GLI2 Neighboring gene predicted gene, 51642 Neighboring gene microRNA 6346

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules. Hur EM, et al. Genes Dev, 2011 Sep 15. PMID 21937714, Free PMC Article
    2. RNA-seq analysis of developing olfactory bulb projection neurons. Kawasawa YI, et al. Mol Cell Neurosci, 2016 Jul. PMID 27073125, Free PMC Article
    3. MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Samora CP, et al. Nat Cell Biol, 2011 Aug 7. PMID 21822276
    4. Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells. Lim BC, et al. J Cell Sci, 2016 Aug 15. PMID 27378169
    5. Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Brinegar AE, et al. Elife, 2017 Aug 11. PMID 28826478, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0622, mKIAA0622

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinetochore binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosomal corona ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CLIP-associating protein 1
    Names
    cytoplasmic linker-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293300.1 → NP_001280229.1  CLIP-associating protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform (4).
      Source sequence(s)
      AC131804, AK042402, BC057312, BC094432, BC094554, BU703855, CF538190, CK640085
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      UniProtKB/TrEMBL
      A0A087WQ31
      Related
      ENSMUSP00000140019.2, ENSMUST00000190571.7
      Conserved Domains (2) summary
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]

    2. NM_001293301.1 → NP_001280230.1  CLIP-associating protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks five exons in the central coding regioin, but maintains the reading frame, compared to variant 4. The encoded isoform (5) is shorter, compared to isoform 4.
      Source sequence(s)
      AK042402, BC094432, BC094554, BU703855, CF538190
      UniProtKB/TrEMBL
      B2RY22, E9Q6L0
      Related
      ENSMUSP00000128089.3, ENSMUST00000165223.8
      Conserved Domains (2) summary
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]

    3. NM_001359328.1 → NP_001346257.1  CLIP-associating protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 802
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    4. NM_001359329.1 → NP_001346258.1  CLIP-associating protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 817
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    5. NM_001359330.1 → NP_001346259.1  CLIP-associating protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Related
      ENSMUSP00000042266.7, ENSMUST00000049404.13
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 767
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    6. NM_001359331.1 → NP_001346260.1  CLIP-associating protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 802
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    7. NM_001359334.1 → NP_001346263.1  CLIP-associating protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42, A0A087WRE8
      Related
      ENSMUSP00000140593.2, ENSMUST00000188710.7
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 817
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    8. NM_001359335.1 → NP_001346264.1  CLIP-associating protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 802
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    9. NM_001359336.1 → NP_001346265.1  CLIP-associating protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:649 → 721
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    10. NM_001359337.1 → NP_001346266.1  CLIP-associating protein 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 775
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    11. NM_001359338.1 → NP_001346267.1  CLIP-associating protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:572 → 713
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    12. NM_001359339.1 → NP_001346268.1  CLIP-associating protein 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 767
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    13. NM_001359340.1 → NP_001346269.1  CLIP-associating protein 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:572 → 713
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    14. NM_001359341.1 → NP_001346270.1  CLIP-associating protein 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 767
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    15. NM_001359342.1 → NP_001346271.1  CLIP-associating protein 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam05956
      Location:566 → 785
      APC_basic; APC basic domain
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    16. NM_001359343.1 → NP_001346272.1  CLIP-associating protein 1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 793
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    17. NM_001359345.1 → NP_001346274.1  CLIP-associating protein 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42, A0A087WRK0
      Related
      ENSMUSP00000140665.3, ENSMUST00000189738.7
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:564 → 780
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    18. NM_001359346.1 → NP_001346275.1  CLIP-associating protein 1 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A087WP42, A0A087WQ95
      Related
      ENSMUSP00000140095.3, ENSMUST00000191445.7
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      cl28033
      Location:572 → 713
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    19. NM_001359347.1 → NP_001346276.1  CLIP-associating protein 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC109294, AC131804, AC136636
      UniProtKB/TrEMBL
      A0A0A6YXZ1
      Conserved Domains (3) summary
      sd00044
      Location:461 → 488
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:1 → 127
      CLASP_N; CLASP N terminal
      cl28033
      Location:154 → 365
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    20. NM_029709.2 → NP_083985.2  CLIP-associating protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks four exons in the central coding region, but maintains the reading frame, compared to variant 4. The encoded isoform (3) is shorter, compared to isoform 4.
      Source sequence(s)
      AK042402, BC094432, BC094554, BU703855, CF538190
      UniProtKB/TrEMBL
      A0A087WS18, B2RY22
      Related
      ENSMUSP00000140860.3, ENSMUST00000189262.7
      Conserved Domains (2) summary
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      118314976..118537192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529920.2 → XP_006529983.1  CLIP-associating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    2. XM_006529929.2 → XP_006529992.1  CLIP-associating protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    3. XM_006529937.2 → XP_006530000.1  CLIP-associating protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    4. XM_006529922.2 → XP_006529985.1  CLIP-associating protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    5. XM_036154261.1 → XP_036010154.1  CLIP-associating protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    6. XM_036154259.1 → XP_036010152.1  CLIP-associating protein 1 isoform X6

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    7. XM_006529938.2 → XP_006530001.1  CLIP-associating protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    8. XM_006529924.2 → XP_006529987.1  CLIP-associating protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    9. XM_006529939.2 → XP_006530002.1  CLIP-associating protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    10. XM_036154255.1 → XP_036010148.1  CLIP-associating protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    11. XM_036154262.1 → XP_036010155.1  CLIP-associating protein 1 isoform X8

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    12. XM_030243458.2 → XP_030099318.1  CLIP-associating protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 810
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    13. XM_036154263.1 → XP_036010156.1  CLIP-associating protein 1 isoform X9

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 783
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    14. XM_030243449.2 → XP_030099309.1  CLIP-associating protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (5) summary
      PHA03307
      Location:651 → 729
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam11179
      Location:572 → 772
      DUF2967; Protein of unknown function (DUF2967)
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    15. XM_006529948.2 → XP_006530011.1  CLIP-associating protein 1 isoform X30

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam05956
      Location:662 → 804
      APC_basic; APC basic domain
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    16. XM_030243485.2 → XP_030099345.1  CLIP-associating protein 1 isoform X29

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam05956
      Location:662 → 804
      APC_basic; APC basic domain
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    17. XM_036154278.1 → XP_036010171.1  CLIP-associating protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    18. XM_011248108.2 → XP_011246410.1  CLIP-associating protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A087WNW8, A0A087WQF1
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam11179
      Location:563 → 763
      DUF2967; Protein of unknown function (DUF2967)
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    19. XM_036154284.1 → XP_036010177.1  CLIP-associating protein 1 isoform X24

      UniProtKB/TrEMBL
      A0A087WNW8
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    20. XM_036154280.1 → XP_036010173.1  CLIP-associating protein 1 isoform X23

      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (4) summary
      PHA03307
      Location:649 → 721
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    21. XM_036154271.1 → XP_036010164.1  CLIP-associating protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A087WP42
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 767
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    22. XM_011248107.2 → XP_011246409.1  CLIP-associating protein 1 isoform X13

      UniProtKB/Swiss-Prot
      Q505G6, Q6DI75, Q6PG14, Q80TV8, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
      UniProtKB/TrEMBL
      E9QKH0
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 767
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    23. XM_036154272.1 → XP_036010165.1  CLIP-associating protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A087WP42
      Conserved Domains (4) summary
      PHA03307
      Location:572 → 713
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    24. XM_030243482.2 → XP_030099342.1  CLIP-associating protein 1 isoform X27

      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam05956
      Location:566 → 788
      APC_basic; APC basic domain
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    25. XM_036154292.1 → XP_036010185.1  CLIP-associating protein 1 isoform X28

      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 808
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    26. XM_036154274.1 → XP_036010167.1  CLIP-associating protein 1 isoform X19

      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (4) summary
      PHA03307
      Location:564 → 799
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    27. XM_036154275.1 → XP_036010168.1  CLIP-associating protein 1 isoform X20

      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    28. XM_036154286.1 → XP_036010179.1  CLIP-associating protein 1 isoform X25

      UniProtKB/TrEMBL
      B2RY22, J3QP81
      Related
      ENSMUSP00000137137.2, ENSMUST00000178710.8
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    29. XM_030243461.2 → XP_030099321.1  CLIP-associating protein 1 isoform X16

      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam05956
      Location:566 → 724
      APC_basic; APC basic domain
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    30. XM_036154288.1 → XP_036010181.1  CLIP-associating protein 1 isoform X26

      UniProtKB/TrEMBL
      B2RY22
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081276.1: Suppressed sequence

      Description
      NM_001081276.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_177548.2: Suppressed sequence

      Description
      NM_177548.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TV8.2 GenPept UniProtKB/Swiss-Prot:Q80TV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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