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    Msln mesothelin [ Mus musculus (house mouse) ]

    Gene ID: 56047, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mslnprovided by MGI
    Official Full Name
    mesothelinprovided by MGI
    Primary source
    MGI:MGI:1888992
    See related
    Ensembl:ENSMUSG00000063011 AllianceGenome:MGI:1888992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPF
    Summary
    Predicted to be involved in cell-matrix adhesion. Predicted to act upstream of or within cell adhesion. Located in extracellular space. Is expressed in several structures, including body cavity or lining; genitourinary system; gut; heart; and respiratory system. Human ortholog(s) of this gene implicated in ovarian cancer; pancreas disease; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human MSLN (mesothelin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 25.5), ovary adult (RPKM 11.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msln in Genome Data Viewer
    Location:
    17 A3.3; 17 12.85 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25967587..25973352, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25748613..25754378, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CTF18, chromosome transmission fidelity factor 18 Neighboring gene STARR-positive B cell enhancer ABC_E3190 Neighboring gene RNA pseudouridylate synthase domain containing 1 Neighboring gene mesothelin-like Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer. Zervos E, et al. J Exp Clin Cancer Res, 2016 Mar 1. PMID 26931187, Free PMC Article
    2. Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice. Zhang J, et al. PLoS One, 2014. PMID 25118887, Free PMC Article
    3. Mesothelin is not required for normal mouse development or reproduction. Bera TK, et al. Mol Cell Biol, 2000 Apr. PMID 10733593, Free PMC Article
    4. Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment. Hilliard TS, et al. Int J Mol Sci, 2021 Nov 18. PMID 34830322, Free PMC Article
    5. Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo. Mahmoud S, et al. Oncotarget, 2016 Nov 15. PMID 27626699, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis.
      Title: Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis.
    2. Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.
      Title: Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.
    3. Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment.
      Title: Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment.
    4. Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
      Title: Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
    5. our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis.
      Title: Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
    6. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
      Title: Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
    7. Results show that mouse mesothelin is similar to human mesothelin. Its stable overexpression in a pancreatic cancer cell line did not increase cell proliferation, suggesting that mesothelin is not necessarily a tumor progression factor.
      Title: Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer.
    8. MSLN has an important role in the growth of lung cancer cells in vivo raising the possibility that inactivation of MPF may be a useful treatment for lung and other MSLN expressing cancers.
      Title: Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice.
    9. The mesothelin expression promotes resistance to certain chemotherapy drugs such as TNF-alpha, paclitaxel, and a combination of platinum and cyclophosphamide.
      Title: The role of mesothelin in tumor progression and targeted therapy.
    10. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion.
      Title: Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mesothelin
    Names
    megakaryocyte potentiating factor
    pre-pro-megakaryocyte-potentiating factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356286.1 → NP_001343215.1  mesothelin isoform 1 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK144391, D86370
      Consensus CDS
      CCDS28526.1
      UniProtKB/Swiss-Prot
      Q61468
      Related
      ENSMUSP00000158474.2, ENSMUST00000237359.2
      Conserved Domains (1) summary
      pfam06060
      Location:1 → 624
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    2. NM_001374653.1 → NP_001361582.1  mesothelin isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC134908
      UniProtKB/TrEMBL
      A0A494B9A6
      Related
      ENSMUSP00000157558.2, ENSMUST00000236137.2
      Conserved Domains (1) summary
      pfam06060
      Location:1 → 628
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    3. NM_018857.2 → NP_061345.1  mesothelin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_061345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) retains an intron in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK144391, AK146799, D86370
      Consensus CDS
      CCDS28526.1
      UniProtKB/Swiss-Prot
      Q61468
      Related
      ENSMUSP00000158357.2, ENSMUST00000238120.2
      Conserved Domains (1) summary
      pfam06060
      Location:1 → 624
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25967587..25973352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61468.1 GenPept UniProtKB/Swiss-Prot:Q61468

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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