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    Lypd4 Ly6/Plaur domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 232973, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lypd4provided by MGI
    Official Full Name
    Ly6/Plaur domain containing 4provided by MGI
    Primary source
    MGI:MGI:2687054
    See related
    Ensembl:ENSMUSG00000062732 AllianceGenome:MGI:2687054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933400F01Rik
    Summary
    Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in plasma membrane raft. Predicted to be anchored component of plasma membrane. Orthologous to human LYPD4 (LY6/PLAUR domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 398.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 13.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24564044..24569180, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24864617..24869924, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cysteine rich protein 2 pseudogene Neighboring gene thymosin beta 10b Neighboring gene doublesex and mab-3 related transcription factor like family C2 Neighboring gene predicted gene, 38966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669208-25669317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669584-25669693 Neighboring gene ribosomal protein S19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility†. Wang D, et al. Biol Reprod, 2020 Apr 24. PMID 32040177
    2. Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Fujihara Y, et al. Proc Natl Acad Sci U S A, 2019 Sep 10. PMID 31455729, Free PMC Article
    3. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertilitydagger.
      Title: LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility†.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC58778

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ly6/PLAUR domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419266.1 → NP_001406195.1  ly6/PLAUR domain-containing protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161441
      UniProtKB/Swiss-Prot
      Q8BVP6

    2. NM_182785.4 → NP_877586.1  ly6/PLAUR domain-containing protein 4 precursor

      See identical proteins and their annotated locations for NP_877586.1

      Status: VALIDATED

      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20964.1
      UniProtKB/Swiss-Prot
      Q8BVP6
      Related
      ENSMUSP00000078287.5, ENSMUST00000079306.11
      Conserved Domains (1) summary
      pfam00021
      Location:142 → 212
      UPAR_LY6; u-PAR/Ly-6 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24564044..24569180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVP6.1 GenPept UniProtKB/Swiss-Prot:Q8BVP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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