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    Adam1b a disintegrin and metallopeptidase domain 1b [ Mus musculus (house mouse) ]

    Gene ID: 280667, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adam1bprovided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 1bprovided by MGI
    Primary source
    MGI:MGI:2429506
    See related
    Ensembl:ENSMUSG00000062438 AllianceGenome:MGI:2429506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftna; Adam1
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida and male gonad development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADAM1B (ADAM metallopeptidase domain 1B (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    5 F; 5 61.83 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121638159..121641498, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121500096..121503435, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6373 Neighboring gene STARR-positive B cell enhancer ABC_E6374 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene transmembrane protein 116 Neighboring gene STARR-positive B cell enhancer ABC_E4785 Neighboring gene mitogen-activated protein kinase 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene STARR-positive B cell enhancer ABC_E9092

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization. Kim E, et al. J Biol Chem, 2006 Mar 3. PMID 16407235
    2. Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm. Kim E, et al. Biochem Biophys Res Commun, 2003 May 2. PMID 12711316
    3. The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha) gene, are localized on mouse chromosome 5. Nishimura H, et al. Gene, 2002 May 29. PMID 12095680
    4. Roles of the disintegrin domains of mouse fertilins alpha and beta in fertilization. Evans JP, et al. Biol Reprod, 1998 Jul. PMID 9675005
    5. Genomic organization of the mouse fertilin beta gene that encodes an ADAM family protein active in sperm-egg fusion. Cho C, et al. Dev Genet, 1997. PMID 9254906

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Localization of ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
      Title: Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
    2. These results suggest that mouse ADAM1b/ADAM2 fertilin may play a crucial role not in the sperm/egg fusion but in the appearance of these two ADAMs on the sperm surface.
      Title: Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 1b
    Names
    PH-30 alpha
    a disintegrin and metalloproteinase domain 1b
    fertilin alpha
    fertilin subunit alpha-b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172125.3 → NP_742123.2  disintegrin and metalloproteinase domain-containing protein 1b precursor

      See identical proteins and their annotated locations for NP_742123.2

      Status: VALIDATED

      Source sequence(s)
      AC129215, AK016558, BB679367, BC140979
      Consensus CDS
      CCDS19636.1
      UniProtKB/Swiss-Prot
      B2RU57, Q8R534, Q9R156
      Related
      ENSMUSP00000078343.4, ENSMUST00000079368.5
      Conserved Domains (5) summary
      smart00608
      Location:489 → 625
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:203 → 395
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:415 → 485
      Disintegrin; Disintegrin
      pfam01421
      Location:203 → 397
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:63 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121638159..121641498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R534.2 GenPept UniProtKB/Swiss-Prot:Q8R534

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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