Ttr transthyretin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttrprovided by MGI
Official Full Name: transthyretinprovided by MGI
Primary source: MGI:MGI:98865
See related: Ensembl:ENSMUSG00000061808 AllianceGenome:MGI:98865
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: prealbumin
Summary: This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]
Expression: Biased expression in liver adult (RPKM 3655.3), liver E18 (RPKM 2930.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A2; 18 11.47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (20797266..20807383)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (20664209..20674326)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transthyretin-Regulated Diabetic Retinopathy Through the VEGFA/PI3K/AKT Pathway.
Title: Transthyretin-Regulated Diabetic Retinopathy Through the VEGFA/PI3K/AKT Pathway.
Transthyretin knockdown recapitulates the insulin-sensitizing effects of exercise and promotes skeletal muscle adaptation to exercise endurance.
Title: Transthyretin knockdown recapitulates the insulin-sensitizing effects of exercise and promotes skeletal muscle adaptation to exercise endurance.
Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.
Title: Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.
Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function.
Title: Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function.
Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia.
Title: Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia.
Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle.
Title: Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle.
Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse.
Title: Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse.
in the diabetic retinopathy environment, TTR might affect the lncRNA MEG3/miR-223-3p axis by the direct binding with PABPC1, and finally repress retinal vessel proliferation.
Title: Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy.
TTR is not synthesized in brain resident cells in the ischemic infarct core and adjacent peri-infarct area.
Title: Transthyretin expression in the postischemic brain.
Knockdown of Ttr in cultured cerebellar granule neurons significantly decreased the delta receptor expression; whereas overexpressing Ttr in cortical neurons increased the delta receptor expression. In vivo analysis of Ttr-/- mice revealed a significant decrease of the surface expression of the delta-GABAA-Rs in cerebellar granule neurons. Together, studies identified Ttr as a novel regulator of the delta-GABAA-Rs.
Title: Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ttr (e-PCR), detects polymorphism
- UniSTS:465412

Ttr (e-PCR), detects polymorphism
- UniSTS:546054

AI787086 (e-PCR)
- UniSTS:163598

RH124760 (e-PCR)
- UniSTS:161582

Ttr (e-PCR), detects polymorphism
- UniSTS:144697

Ttr (e-PCR), detects polymorphism
- UniSTS:144698

Ttr (e-PCR), detects polymorphism
- UniSTS:516159

NoName (e-PCR)
- UniSTS:548467

D17860 (e-PCR)
- UniSTS:160725

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transthyretin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013697.5 → NP_038725.1 transthyretin precursor

See identical proteins and their annotated locations for NP_038725.1

Status: REVIEWED

Source sequence(s)

AC129078, CD742426

Consensus CDS

CCDS29085.1

UniProtKB/Swiss-Prot

P07309

UniProtKB/TrEMBL

Q5M9K1, Q9D6A4

Related

ENSMUSP00000074783.4, ENSMUST00000075312.5

Conserved Domains (1) summary

smart00095
Location:27 → 147

TR_THY; Transthyretin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

20797266..20807383

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250412.1 → XP_030106272.1 transthyretin isoform X1

UniProtKB/Swiss-Prot

P07309

UniProtKB/TrEMBL

Q5M9K1, Q9D6A4

Conserved Domains (1) summary

smart00095
Location:27 → 147

TR_THY; Transthyretin