U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Atp8b4 ATPase, class I, type 8B, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 241633, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Atp8b4provided by MGI
    Official Full Name
    ATPase, class I, type 8B, member 4provided by MGI
    Primary source
    MGI:MGI:1859664
    See related
    Ensembl:ENSMUSG00000060131 AllianceGenome:MGI:1859664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Im
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane and trans-Golgi network. Orthologous to human ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E18 (RPKM 2.3), liver E14 (RPKM 2.0) and 10 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126162893..126342589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126320973..126500669, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125977713-125977822 Neighboring gene DTW domain containing 1 Neighboring gene predicted gene, 54149 Neighboring gene STARR-seq mESC enhancer starr_05598 Neighboring gene STARR-seq mESC enhancer starr_05599 Neighboring gene STARR-seq mESC enhancer starr_05600 Neighboring gene STARR-positive B cell enhancer ABC_E2643 Neighboring gene STARR-seq mESC enhancer starr_05601 Neighboring gene STARR-seq mESC enhancer starr_05602 Neighboring gene STARR-seq mESC enhancer starr_05603 Neighboring gene STARR-positive B cell enhancer mm9_chr2:126188755-126189056 Neighboring gene Brca1 associated protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:126292531-126292684 Neighboring gene STARR-positive B cell enhancer ABC_E4495 Neighboring gene STARR-seq mESC enhancer starr_05604 Neighboring gene STARR-seq mESC enhancer starr_05605 Neighboring gene STARR-seq mESC enhancer starr_05606 Neighboring gene predicted gene, 26697 Neighboring gene solute carrier family 27 (fatty acid transporter), member 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC161341, A530043E15

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    probable phospholipid-transporting ATPase IM
    Names
    ATPase 8B4, p type
    ATPase B4, class I
    NP_001074413.2
    NP_001346904.1
    XP_006499558.1
    XP_006499561.1
    XP_006499562.1
    XP_006499563.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080944.3 → NP_001074413.2  probable phospholipid-transporting ATPase IM

      See identical proteins and their annotated locations for NP_001074413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK173307, AL929245, BC130260
      Consensus CDS
      CCDS50698.1
      UniProtKB/TrEMBL
      A2ANX3
      Related
      ENSMUSP00000047302.7, ENSMUST00000040149.13
      Conserved Domains (1) summary
      cd02073
      Location:31 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. NM_001359975.1 → NP_001346904.1  probable phospholipid-transporting ATPase IM

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL831764, AL929245
      Consensus CDS
      CCDS50698.1
      UniProtKB/TrEMBL
      A2ANX3
      Related
      ENSMUSP00000046444.6, ENSMUST00000040128.12
      Conserved Domains (1) summary
      cd02073
      Location:31 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126162893..126342589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499495.1 → XP_006499558.1  probable phospholipid-transporting ATPase IM isoform X1

      See identical proteins and their annotated locations for XP_006499558.1

      UniProtKB/TrEMBL
      A2ANX3
      Conserved Domains (1) summary
      cd02073
      Location:31 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. XM_006499500.4 → XP_006499563.1  probable phospholipid-transporting ATPase IM isoform X4

      UniProtKB/TrEMBL
      Q69Z59
      Conserved Domains (1) summary
      cd02073
      Location:31 → 707
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    3. XM_006499498.5 → XP_006499561.1  probable phospholipid-transporting ATPase IM isoform X2

      UniProtKB/TrEMBL
      Q69Z59
      Conserved Domains (1) summary
      cd02073
      Location:31 → 707
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    4. XM_006499499.5 → XP_006499562.1  probable phospholipid-transporting ATPase IM isoform X3

      UniProtKB/TrEMBL
      Q69Z59
      Conserved Domains (1) summary
      cd02073
      Location:31 → 720
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous