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    Atl2 atlastin GTPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 56298, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Atl2provided by MGI
    Official Full Name
    atlastin GTPase 2provided by MGI
    Primary source
    MGI:MGI:1929492
    See related
    Ensembl:ENSMUSG00000059811 AllianceGenome:MGI:1929492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aip-2; Arl6ip2; 2010110I21Rik
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and identical protein binding activity. Predicted to be involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Predicted to be located in endoplasmic reticulum tubular network membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; nasal cavity epithelium; and skin. Orthologous to human ATL2 (atlastin GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.7), thymus adult (RPKM 7.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E3; 17 50.3 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80155819..80203633, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (79848352..79896204, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43287 Neighboring gene predicted gene, 33055 Neighboring gene predicted gene, 49984 Neighboring gene STARR-seq mESC enhancer starr_43288 Neighboring gene STARR-positive B cell enhancer ABC_E9444 Neighboring gene predicted gene, 41625 Neighboring gene STARR-seq mESC enhancer starr_43290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:80354198-80354418 Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene Neighboring gene STARR-seq mESC enhancer starr_43292 Neighboring gene STARR-positive B cell enhancer mm9_chr17:80381942-80382243 Neighboring gene STARR-positive B cell enhancer ABC_E4228 Neighboring gene STARR-seq mESC enhancer starr_43295 Neighboring gene heterogeneous nuclear ribonucleoprotein L-like Neighboring gene predicted gene, 22215

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression. Le Guillou S, et al. Biochem Biophys Res Commun, 2019 Apr 30. PMID 30879769
    2. Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology. Zhao G, et al. Exp Cell Res, 2016 Nov 15. PMID 27669642
    3. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. Ingley E, et al. FEBS Lett, 1999 Oct 1. PMID 10508919
    4. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Liu Y, et al. Gene Expr Patterns, 2002 Dec. PMID 12617806
    5. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the increase in lipid droplet size observed in the mammary epithelial cells of transgenic mice might result from changes to lipid droplet formation and secretion because of direct modifications to Atl2 expression and indirect changes to endoplasmic reticulum morphology resulting from the overexpression of miR-30b-5p
      Title: Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression.
    2. Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells.
      Title: Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum tubular network membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum tubular network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    atlastin-2
    Names
    ADP-ribosylation factor-like 6 interacting protein 2
    ADP-ribosylation factor-like protein 6-interacting protein 2
    ADP-ribosylation-like factor 6 interacting protein 2
    ARL-6 interacting protein-2
    NP_001273576.1
    NP_001344681.1
    NP_001344682.1
    NP_062691.3
    NP_835151.2
    XP_006524718.1
    XP_036016582.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286647.1 → NP_001273576.1  atlastin-2 isoform 3

      See identical proteins and their annotated locations for NP_001273576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in an additional internal 5' UTR segment, translation initiation at a downstream start codon, and an alternate 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK008381, AK032050, AK038697, BM938279, BY244533
      UniProtKB/TrEMBL
      Q8BYP9
      Conserved Domains (1) summary
      cl21455
      Location:1 → 170
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001357752.1 → NP_001344681.1  atlastin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117261, BM938279
      Conserved Domains (1) summary
      pfam02263
      Location:70 → 341
      GBP; Guanylate-binding protein, N-terminal domain

    3. NM_001357753.1 → NP_001344682.1  atlastin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117261, BM938279
      Conserved Domains (1) summary
      pfam02263
      Location:70 → 341
      GBP; Guanylate-binding protein, N-terminal domain

    4. NM_019717.3 → NP_062691.3  atlastin-2 isoform 1

      See identical proteins and their annotated locations for NP_062691.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK008381, AK032050, AK038697, BC060501, BM938279
      Consensus CDS
      CCDS37700.1
      UniProtKB/Swiss-Prot
      Q3UX01, Q6PA06, Q7TMM3
      Related
      ENSMUSP00000064758.6, ENSMUST00000068282.7
      Conserved Domains (1) summary
      pfam02263
      Location:70 → 341
      GBP; Guanylate-binding protein, N-terminal domain

    5. NM_178050.4 → NP_835151.2  atlastin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK008381, AK032050, AK038697, AK135988, BC060501, BM938279
      Consensus CDS
      CCDS37701.1
      UniProtKB/TrEMBL
      E9QND8
      Related
      ENSMUSP00000108056.2, ENSMUST00000112437.8
      Conserved Domains (1) summary
      cl21455
      Location:1 → 170
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80155819..80203633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160689.1 → XP_036016582.1  atlastin-2 isoform X2

      Conserved Domains (1) summary
      pfam02263
      Location:16 → 287
      GBP; Guanylate-binding protein, N-terminal domain

    2. XM_006524655.5 → XP_006524718.1  atlastin-2 isoform X1

      Conserved Domains (1) summary
      pfam02263
      Location:70 → 341
      GBP; Guanylate-binding protein, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PA06.1 GenPept UniProtKB/Swiss-Prot:Q6PA06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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