Reg1 regenerating islet-derived 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reg1provided by MGI
Official Full Name: regenerating islet-derived 1provided by MGI
Primary source: MGI:MGI:97895
See related: Ensembl:ENSMUSG00000059654 AllianceGenome:MGI:97895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PSP; PTP
Summary: Predicted to enable several functions, including growth factor activity; identical protein binding activity; and peptidoglycan binding activity. Involved in several processes, including pancreas regeneration; phosphatidylinositol 3-kinase signaling; and type B pancreatic cell differentiation. Acts upstream of or within with a positive effect on gene expression. Located in collagen-containing extracellular matrix. Is expressed in several structures, including esophagus; lung; and pancreas. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 1980.7), small intestine adult (RPKM 924.8) and 1 other tissue See more
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Genomic context

Location:: 6 C3; 6 34.77 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (78402966..78405651)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (78425983..78428668)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratinocyte Regnase-1, a Downregulator of Skin Inflammation, Contributes to Protection against Tumor Promotion by Limiting Cyclooxygenase-2 Expression.
Title: Keratinocyte Regnase-1, a Downregulator of Skin Inflammation, Contributes to Protection against Tumor Promotion by Limiting Cyclooxygenase-2 Expression.
Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.
Title: Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.
miR-7 directly targets reg1 expression in murine pancreatic cells.
Title: MicroRNA-7 directly targets Reg1 in pancreatic cells.
Study utilizing contact hypersensitivity model in Reg1 knockout mice conclude that the autostimulatory loop of IL-36 signaling in keratinocytes is, at least in part, regulated by Reg1 to limit excessive skin inflammation.
Title: Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.
These results suggest that Reg1, which is released from acinar-like cell clusters touching Langerhans islets with thin interstitial surrounding to islet beta cell clusters, has a crucial role in beta cell regeneration in ncephalomyocarditis virus-induced diabetes.
Title: Crucial role of Reg I from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice.
The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas.
Title: The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
Title: Role of regenerating gene I in claudin expression and barrier function in the small intestine.
Members of the Reg gene family show distinct profiles of expression in the GI tract, and Reg I independently plays a role in protecting the GI mucosa against NSAID-induced injury.
Title: Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin.
Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats
Title: Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.
This study implicates the Reg1 pathway in beta-cell regeneration and describes altered programming of gene expression in low protein offspring.
Title: Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Reg1 (e-PCR), detects polymorphism
- UniSTS:259509

D14010 (e-PCR)
- UniSTS:179396

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in pancreas regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acinar cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in type B pancreatic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in zymogen granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lithostathine-1

Names: REG 1; islet of Langerhans regenerating protein 1; pancreatic stone protein 1; pancreatic thread protein 1; regenerating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.