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    Fry FRY microtubule binding protein [ Mus musculus (house mouse) ]

    Gene ID: 320365, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fryprovided by MGI
    Official Full Name
    FRY microtubule binding proteinprovided by MGI
    Primary source
    MGI:MGI:2443895
    See related
    Ensembl:ENSMUSG00000056602 AllianceGenome:MGI:2443895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cg003; 13CDNA73; mKIAA4143; D930046M03; 9330186A19Rik
    Summary
    Enables enzyme inhibitor activity. Involved in negative regulation of tubulin deacetylation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in cell cortex and site of polarized growth. Is expressed in several structures, including genitourinary system; nervous system; respiratory system cartilage; sensory organ; and skeleton. Orthologous to human FRY (FRY microtubule binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 11.0), subcutaneous fat pad adult (RPKM 10.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fry in Genome Data Viewer
    Location:
    5 G3; 5 89.36 cM
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150042083..150421218)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (150118618..150497753)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene relaxin/insulin-like family peptide receptor 2 Neighboring gene predicted gene, 38755 Neighboring gene STARR-seq mESC enhancer starr_14950 Neighboring gene predicted gene, 52797 Neighboring gene STARR-seq mESC enhancer starr_14951 Neighboring gene STARR-seq mESC enhancer starr_14952 Neighboring gene STARR-positive B cell enhancer mm9_chr5:151026173-151026473 Neighboring gene STARR-seq mESC enhancer starr_14953 Neighboring gene STARR-positive B cell enhancer ABC_E11311 Neighboring gene predicted gene, 36299 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene predicted gene, 57745 Neighboring gene zygote arrest 1-like Neighboring gene predicted gene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. Nagai T, et al. J Cell Sci, 2013 Oct 1. PMID 23886946
    2. A transgenic insertion causing cryptorchidism in mice. Overbeek PA, et al. Genesis, 2001 May. PMID 11353515
    3. Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. Rios JJ, et al. J Bone Miner Res, 2021 Aug. PMID 33905568, Free PMC Article
    4. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017
    5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4143

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of tubulin deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein furry homolog
    Names
    furry homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172887.2 → NP_766475.2  protein furry homolog

      See identical proteins and their annotated locations for NP_766475.2

      Status: VALIDATED

      Source sequence(s)
      AC084217, AK054402, AK086708, BC096532, BF471208, BU057159, CA327618, CA328551, CB520664, CF532608, CJ103680
      Consensus CDS
      CCDS51708.1
      UniProtKB/Swiss-Prot
      E9Q8I9, Q4VA57, Q5DTL4, Q8BIW6, Q8BUA0, Q8CG91
      UniProtKB/TrEMBL
      A0A5F8MPN1
      Related
      ENSMUSP00000084454.6, ENSMUST00000087204.9
      Conserved Domains (3) summary
      pfam14222
      Location:165 → 672
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2050 → 2303
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1141 → 1513
      MOR2-PAG1_mid; Cell morphogenesis central region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      150042083..150421218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504932.3 → XP_006504995.1  protein furry homolog isoform X8

      See identical proteins and their annotated locations for XP_006504995.1

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:115 → 621
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2000 → 2253
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1091 → 1456
      MOR2-PAG1_mid; Cell morphogenesis central region

    2. XM_006504933.3 → XP_006504996.1  protein furry homolog isoform X8

      See identical proteins and their annotated locations for XP_006504996.1

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:115 → 621
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2000 → 2253
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1091 → 1456
      MOR2-PAG1_mid; Cell morphogenesis central region

    3. XM_030254574.2 → XP_030110434.1  protein furry homolog isoform X8

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:115 → 621
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2000 → 2253
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1091 → 1456
      MOR2-PAG1_mid; Cell morphogenesis central region

    4. XM_011241024.2 → XP_011239326.1  protein furry homolog isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:210 → 716
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2095 → 2348
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1186 → 1551
      MOR2-PAG1_mid; Cell morphogenesis central region

    5. XM_006504926.2 → XP_006504989.1  protein furry homolog isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:210 → 716
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2095 → 2348
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1186 → 1551
      MOR2-PAG1_mid; Cell morphogenesis central region

    6. XM_006504928.2 → XP_006504991.1  protein furry homolog isoform X4

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:210 → 716
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2095 → 2348
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1186 → 1551
      MOR2-PAG1_mid; Cell morphogenesis central region

    7. XM_006504927.2 → XP_006504990.1  protein furry homolog isoform X3

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:210 → 716
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2095 → 2348
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1186 → 1551
      MOR2-PAG1_mid; Cell morphogenesis central region

    8. XM_006504929.2 → XP_006504992.1  protein furry homolog isoform X5

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:210 → 716
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2095 → 2348
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1186 → 1551
      MOR2-PAG1_mid; Cell morphogenesis central region

    9. XM_006504930.5 → XP_006504993.1  protein furry homolog isoform X6

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Conserved Domains (3) summary
      pfam14222
      Location:165 → 671
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2050 → 2303
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1141 → 1506
      MOR2-PAG1_mid; Cell morphogenesis central region

    10. XM_006504931.3 → XP_006504994.1  protein furry homolog isoform X7

      UniProtKB/TrEMBL
      A0A5F8MPN1
      Related
      ENSMUSP00000158877.2, ENSMUST00000239118.2
      Conserved Domains (3) summary
      pfam14222
      Location:162 → 668
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2047 → 2300
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1138 → 1503
      MOR2-PAG1_mid; Cell morphogenesis central region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178781.2: Suppressed sequence

      Description
      NM_178781.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q8I9.1 GenPept UniProtKB/Swiss-Prot:E9Q8I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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