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    Actr3b ARP3 actin-related protein 3B [ Mus musculus (house mouse) ]

    Gene ID: 242894, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Actr3bprovided by MGI
    Official Full Name
    ARP3 actin-related protein 3Bprovided by MGI
    Primary source
    MGI:MGI:2661120
    See related
    Ensembl:ENSMUSG00000056367 AllianceGenome:MGI:2661120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARP11; Arp3b; Arp3beta; 9630005C02
    Summary
    Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Is expressed in main olfactory bulb; olfactory lobe; and telencephalon ventricular layer. Orthologous to several human genes including ACTR3B (actin related protein 3B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 22.5), frontal lobe adult (RPKM 19.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B1; 5 12.35 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25964960..26055686)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (25759941..25850691)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 2 Neighboring gene predicted gene, 54325 Neighboring gene STARR-seq mESC enhancer starr_12674 Neighboring gene predicted gene, 42237 Neighboring gene STARR-seq mESC enhancer starr_12675 Neighboring gene predicted gene, 21655 Neighboring gene predicted gene, 21663

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Elsen GE, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431145, Free PMC Article
    2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91290

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 3B
    Names
    ARP3 actin-related protein 3 homolog B
    actin-related protein 3-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004365.3 → NP_001004365.1  actin-related protein 3B isoform 1

      See identical proteins and their annotated locations for NP_001004365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116412
      Consensus CDS
      CCDS19136.1
      UniProtKB/Swiss-Prot
      Q641P0, Q7TSH1
      UniProtKB/TrEMBL
      Q3TGE1
      Related
      ENSMUSP00000085578.5, ENSMUST00000088244.6
      Conserved Domains (2) summary
      COG5277
      Location:1 → 410
      COG5277; Actin-related protein [Cytoskeleton]
      PTZ00280
      Location:2 → 417
      PTZ00280; Actin-related protein 3; Provisional

    2. NM_001310504.2 → NP_001297433.1  actin-related protein 3B isoform 2

      See identical proteins and their annotated locations for NP_001297433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC116412
      Consensus CDS
      CCDS80232.1
      UniProtKB/Swiss-Prot
      Q641P0
      Related
      ENSMUSP00000121629.2, ENSMUST00000128727.8
      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 329
      PTZ00280; Actin-related protein 3; Provisional

    3. NM_001424742.1 → NP_001411671.1  actin-related protein 3B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116412

    4. NM_001424743.1 → NP_001411672.1  actin-related protein 3B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116412

    5. NM_001424744.1 → NP_001411673.1  actin-related protein 3B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116412

    6. NM_001424745.1 → NP_001411674.1  actin-related protein 3B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116412

    7. NM_001424746.1 → NP_001411675.1  actin-related protein 3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116412

    8. NM_001424749.1 → NP_001411678.1  actin-related protein 3B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116412

    9. NM_001424750.1 → NP_001411679.1  actin-related protein 3B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC116412

    10. NM_001424751.1 → NP_001411680.1  actin-related protein 3B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC116412

    11. NM_001424752.1 → NP_001411681.1  actin-related protein 3B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC116412

    RNA

    1. NR_188892.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116412

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      25964960..26055686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165122.1 → XP_036021015.1  actin-related protein 3B isoform X2

      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 329
      PTZ00280; Actin-related protein 3; Provisional

    2. XM_017320880.3 → XP_017176369.1  actin-related protein 3B isoform X3

      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 288
      PTZ00280; Actin-related protein 3; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641P0.1 GenPept UniProtKB/Swiss-Prot:Q641P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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