Lrguk leucine-rich repeats and guanylate kinase domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrgukprovided by MGI
Official Full Name: leucine-rich repeats and guanylate kinase domain containingprovided by MGI
Primary source: MGI:MGI:1921604
See related: Ensembl:ENSMUSG00000056215 AllianceGenome:MGI:1921604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4921528H16Rik
Summary: Predicted to enable guanylate kinase activity. Involved in axoneme assembly and spermatogenesis. Located in acrosomal vesicle and manchette. Is expressed in olfactory epithelium. Orthologous to human LRGUK (leucine rich repeats and guanylate kinase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.9), CNS E18 (RPKM 0.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 14.75 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (34006183..34110969)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (34029245..34134034)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified LRGUK-1 as a protein critically involved in multiple aspects of sperm assembly and function. LRGUK-1 is required for appropriate acrosome attachment to the sperm heard, sperm head shaping via the manchette and tail growth from the basal body; specific loss of LRGUK-1 function results in oligoasthenoteratospermia in mice.
Title: LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables guanylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axoneme assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in manchette	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat and guanylate kinase domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401521.1 → NP_001388450.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 1

Status: VALIDATED

Source sequence(s)

AC153817

UniProtKB/TrEMBL

A0A2I3BQA5

Related

ENSMUSP00000153993.2, ENSMUST00000228187.2
NM_001401523.1 → NP_001388452.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 2

Status: VALIDATED

Source sequence(s)

AC153817

UniProtKB/TrEMBL

A0A8Q0LUS2

Related

ENSMUSP00000159470.1, ENSMUST00000240538.1
NM_028886.2 → NP_083162.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 3

See identical proteins and their annotated locations for NP_083162.1

Status: VALIDATED

Source sequence(s)

AC153817

Consensus CDS

CCDS51745.1

UniProtKB/Swiss-Prot

Q9D5S7

Related

ENSMUSP00000065146.4, ENSMUST00000070189.10

Conserved Domains (6) summary

cd00071
Location:416 → 537

GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...

cd00116
Location:150 → 339

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:131 → 150

LRR_RI; leucine-rich repeat [structural motif]

pfam00625
Location:417 → 599

Guanylate_kin; Guanylate kinase

pfam12799
Location:260 → 300

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:282 → 339

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

34006183..34110969

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506713.5 → XP_006506776.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X1

Conserved Domains (4) summary

PHA03247
Location:678 → 1233

PHA03247; large tegument protein UL36; Provisional

cd00071
Location:416 → 537

GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...

sd00033
Location:131 → 150

LRR_RI; leucine-rich repeat [structural motif]

NF033189
Location:132 → 333

internalin_A; class 1 internalin InlA
XM_011241496.3 → XP_011239798.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:132 → 649

PHA03247; large tegument protein UL36; Provisional

PRK12323
Location:14 → 230

PRK12323; DNA polymerase III subunit gamma/tau