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    Zfp647 zinc finger protein 647 [ Mus musculus (house mouse) ]

    Gene ID: 239546, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp647provided by MGI
    Official Full Name
    zinc finger protein 647provided by MGI
    Primary source
    MGI:MGI:3052806
    See related
    Ensembl:ENSMUSG00000054967 AllianceGenome:MGI:3052806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Es492; Znf250; 6030449J21
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; limb; nervous system; and retina. Orthologous to human ZNF250 (zinc finger protein 250). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 7.2), CNS E14 (RPKM 6.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 36.28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76794570..76809907, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76910370..76925693, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E5492 Neighboring gene COMM domain containing 5 Neighboring gene ribosomal protein L8 Neighboring gene zinc finger protein 113 pseudogene Neighboring gene predicted gene, 46534 Neighboring gene RIKEN cDNA 1110038F14 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies. Briers S, et al. J Cell Sci, 2009 Apr 1. PMID 19258395, Free PMC Article
    2. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 250
    Names
    KRAB zinc-finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168276.2 → NP_001161748.1  zinc finger protein 250

      See identical proteins and their annotated locations for NP_001161748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC157554
      Consensus CDS
      CCDS27596.1
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57
      Conserved Domains (3) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      COG5048
      Location:172 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001416083.1 → NP_001403012.1  zinc finger protein 250

      Status: VALIDATED

      Source sequence(s)
      AC157554
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57

    3. NM_001416084.1 → NP_001403013.1  zinc finger protein 250

      Status: VALIDATED

      Source sequence(s)
      AC157554
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57

    4. NM_001416085.1 → NP_001403014.1  zinc finger protein 250

      Status: VALIDATED

      Source sequence(s)
      AC157554
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57

    5. NM_001416086.1 → NP_001403015.1  zinc finger protein 250

      Status: VALIDATED

      Source sequence(s)
      AC157554
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57

    6. NM_001416087.1 → NP_001403016.1  zinc finger protein 250

      Status: VALIDATED

      Source sequence(s)
      AC157554
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57

    7. NM_001416088.1 → NP_001403017.1  zinc finger protein 250

      Status: VALIDATED

      Source sequence(s)
      AC157554
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57

    8. NM_001416089.1 → NP_001403018.1  zinc finger protein 250

      Status: VALIDATED

      Source sequence(s)
      AC157554
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57

    9. NM_172817.4 → NP_766405.2  zinc finger protein 250

      See identical proteins and their annotated locations for NP_766405.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC157554
      Consensus CDS
      CCDS27596.1
      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57
      Related
      ENSMUSP00000155685.2, ENSMUST00000229055.2
      Conserved Domains (3) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      COG5048
      Location:172 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76794570..76809907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159398.1 → XP_036015291.1  zinc finger protein 250 isoform X1

      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57
      Conserved Domains (3) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      COG5048
      Location:172 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030248551.2 → XP_030104411.1  zinc finger protein 250 isoform X1

      UniProtKB/Swiss-Prot
      Q7TNU6, Q8BJ57
      Conserved Domains (3) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      COG5048
      Location:172 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNU6.1 GenPept UniProtKB/Swiss-Prot:Q7TNU6

    Gene LinkOut

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