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    Tprkb Tp53rk binding protein [ Mus musculus (house mouse) ]

    Gene ID: 69786, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tprkbprovided by MGI
    Official Full Name
    Tp53rk binding proteinprovided by MGI
    Primary source
    MGI:MGI:1917036
    See related
    Ensembl:ENSMUSG00000054226 AllianceGenome:MGI:1917036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DRWMS1; Cgi-121; mDRWMS1; 0610033G21Rik; 1810034M08Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification and telomere maintenance via recombination. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 5. Orthologous to human TPRKB (TP53RK binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 15.1), cerebellum adult (RPKM 12.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 C3; 6 37.53 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85888842..85907266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85911860..85930284)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16511 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene STARR-seq mESC enhancer starr_16512 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E11321 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 1 Neighboring gene syndecan binding protein pseudogene Neighboring gene N-acetyltransferase 8B, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:85887170-85887279 Neighboring gene prohibitin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. Iwata S, et al. G3 (Bethesda), 2021 Aug 7. PMID 34849815, Free PMC Article
    2. Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein. Miyoshi A, et al. Biochem Biophys Res Commun, 2003 Apr 4. PMID 12659830
    3. Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus. Daigo Y, et al. J Gastroenterol, 2004. PMID 15065000
    4. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Braun DA, et al. Nat Genet, 2017 Oct. PMID 28805828, Free PMC Article
    5. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EKC/KEOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EKC/KEOPS complex subunit Tprkb
    Names
    PRPK-binding protein
    Prpk (p53-related protein kinase)-binding protein
    TP53RK-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170488.1 → NP_001163959.1  EKC/KEOPS complex subunit Tprkb isoform a

      See identical proteins and their annotated locations for NP_001163959.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC158679, BM935112, BM948212, BY108059
      Consensus CDS
      CCDS20305.1
      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Related
      ENSMUSP00000109382.2, ENSMUST00000113753.8
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    2. NM_001362064.1 → NP_001348993.1  EKC/KEOPS complex subunit Tprkb isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC158679, AC161888
      Consensus CDS
      CCDS20305.1
      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    3. NM_001362065.1 → NP_001348994.1  EKC/KEOPS complex subunit Tprkb isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC158679
      Consensus CDS
      CCDS20305.1
      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    4. NM_001362066.1 → NP_001348995.1  EKC/KEOPS complex subunit Tprkb isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC158679
      Consensus CDS
      CCDS20305.1
      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Related
      ENSMUSP00000109381.2, ENSMUST00000113752.8
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    5. NM_001362067.1 → NP_001348996.1  EKC/KEOPS complex subunit Tprkb isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC158679, BC027413, CO424671
      Consensus CDS
      CCDS90081.1
      UniProtKB/TrEMBL
      G3X9K8, Q8R2M6
      Related
      ENSMUSP00000144660.2, ENSMUST00000202803.4
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 148
      CGI-121; Kinase binding protein CGI-121

    6. NM_176842.3 → NP_789812.1  EKC/KEOPS complex subunit Tprkb isoform a

      See identical proteins and their annotated locations for NP_789812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC158679, BM948212, BY108059
      Consensus CDS
      CCDS20305.1
      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Related
      ENSMUSP00000063927.8, ENSMUST00000067137.14
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85888842..85907266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321732.2 → XP_017177221.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    2. XM_030255586.1 → XP_030111446.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    3. XM_030255587.1 → XP_030111447.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    4. XM_006506567.4 → XP_006506630.1  EKC/KEOPS complex subunit Tprkb isoform X1

      See identical proteins and their annotated locations for XP_006506630.1

      UniProtKB/Swiss-Prot
      Q8QZZ7
      UniProtKB/TrEMBL
      Q8R2M6
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZZ7.1 GenPept UniProtKB/Swiss-Prot:Q8QZZ7

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