Lgals7 lectin, galactose binding, soluble 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgals7provided by MGI
Official Full Name: lectin, galactose binding, soluble 7provided by MGI
Primary source: MGI:MGI:1316742
See related: Ensembl:ENSMUSG00000053522 AllianceGenome:MGI:1316742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pig1; Galectin-7
Summary: Predicted to enable carbohydrate binding activity and galactoside binding activity. Predicted to be involved in negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of interferon-gamma production; and positive regulation of gene expression. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm and extracellular space. Predicted to be active in cytosol and nucleus. Is expressed in maxillary process and upper jaw. Orthologous to several human genes including LGALS7 (galectin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 383.9), lung adult (RPKM 28.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28563258..28565711)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28863796..28866285)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1.
Title: Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1.
Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs.
Title: Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs.
Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression.
Title: Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression.
Enhanced galectin-7 expression favors wound healing.
Title: Enhanced galectin-7 expression favors wound healing.
Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.
Title: Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.
Galectin-7 overexpression destroys airway epithelial barrier in transgenic mice.
Title: Galectin-7 overexpression destroys airway epithelial barrier in transgenic mice.
Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.
Title: Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.
Serum galectin-7 was not useful for predicting prognosis in threatened abortion
Title: Serum Galectin 7 is Not Useful to Predict Abortion in the First Trimester.
Diabetic mice model shows that increased O-linked N-Acetyl-glucosamine (O-GlcNAc) is responsible for reduced Gal-7 expression in keratinocytes exposed to high glucose environment.
Title: High-glucose environment induced intracellular O-GlcNAc glycosylation and reduced galectin-7 expression in keratinocytes: Implications on impaired diabetic wound healing.
The data suggest that gal-7 could potentiate the phenotype of HER-2 positive primary breast cancer.
Title: Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galectin-7

Names: gal-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.