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    Grk4 G protein-coupled receptor kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 14772, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Grk4provided by MGI
    Official Full Name
    G protein-coupled receptor kinase 4provided by MGI
    Primary source
    MGI:MGI:95801
    See related
    Ensembl:ENSMUSG00000052783 AllianceGenome:MGI:95801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRK; Gprk4; Gprk2l; A830025H08Rik
    Summary
    Predicted to enable rhodopsin kinase activity. Predicted to be involved in G protein-coupled receptor internalization and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol; dendrite; and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 7.6), bladder adult (RPKM 0.8) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B2; 5 17.91 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34817641..34912649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34660250..34755305)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34979450-34979637 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:35002815-35002998 Neighboring gene NOP14 nucleolar protein Neighboring gene predicted gene 15522 Neighboring gene microRNA 467g Neighboring gene STARR-positive B cell enhancer ABC_E1050 Neighboring gene huntingtin Neighboring gene Myb/SANT-like DNA-binding domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury. Yang D, et al. Kidney Int, 2023 Apr. PMID 36669643
    2. LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis. Li X, et al. Cells, 2022 Dec 9. PMID 36552750, Free PMC Article
    3. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Usui I, et al. Mol Endocrinol, 2005 Nov. PMID 15994203
    4. Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. Banna FKE, et al. Sci Rep, 2022 Jun 4. PMID 35661789, Free PMC Article
    5. The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum. Maurin T, et al. Nucleic Acids Res, 2015 Sep 30. PMID 26250109, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression.
      Title: Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression.
    2. Effect of GRK4 on renal gastrin receptor regulation in hypertension.
      Title: Effect of GRK4 on renal gastrin receptor regulation in hypertension.
    3. Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.
      Title: Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.
    4. LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis.
      Title: LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis.
    5. GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
      Title: GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
    6. GRK4gamma gene variants (A>65L, A>142V, and A>486V) in mice causes Hypertension, although Salt Sensitivity depends on which is GRK4gamma variant is present.
      Title: Gastrorenal Axis.
    7. GRK2 inhibits WNT signaling in osteoblasts
      Title: Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).
    8. The role of GRK2 in chronic ET-1-induced insulin resistance was investigated.
      Title: G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rhodopsin kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in desensitization of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 4
    Names
    G protein-coupled receptor kinase 2, groucho gene related
    g protein-coupled receptor kinase GRK4
    NP_001074212.1
    NP_062370.2
    XP_006503805.1
    XP_017176159.1
    XP_017176160.1
    XP_030109995.1
    XP_030109996.1
    XP_030109997.1
    XP_030109998.1
    XP_036020689.1
    XP_036020690.1
    XP_036020691.1
    XP_036020692.1
    XP_036020693.1
    XP_036020694.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080743.2 → NP_001074212.1  G protein-coupled receptor kinase 4 isoform 2

      See identical proteins and their annotated locations for NP_001074212.1

      Status: VALIDATED

      Source sequence(s)
      AC151669
      Consensus CDS
      CCDS39070.1
      UniProtKB/TrEMBL
      Q8BP13
      Related
      ENSMUSP00000074223.5, ENSMUST00000074651.11
      Conserved Domains (1) summary
      cl02565
      Location:51 → 145
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_019497.3 → NP_062370.2  G protein-coupled receptor kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_062370.2

      Status: VALIDATED

      Source sequence(s)
      AC151669
      Consensus CDS
      CCDS19219.1
      UniProtKB/Swiss-Prot
      O70291, Q3V151
      Related
      ENSMUSP00000001112.8, ENSMUST00000001112.14
      Conserved Domains (3) summary
      smart00220
      Location:186 → 448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05605
      Location:185 → 469
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      34817641..34912649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164798.1 → XP_036020691.1  G protein-coupled receptor kinase 4 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036164800.1 → XP_036020693.1  G protein-coupled receptor kinase 4 isoform X7

      Conserved Domains (2) summary
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185 → 352
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006503742.5 → XP_006503805.1  G protein-coupled receptor kinase 4 isoform X8

      Conserved Domains (2) summary
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185 → 352
      PKc_like; Protein Kinases, catalytic domain

    4. XM_017320670.3 → XP_017176159.1  G protein-coupled receptor kinase 4 isoform X4

      Conserved Domains (2) summary
      cd05605
      Location:185 → 468
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    5. XM_017320671.3 → XP_017176160.1  G protein-coupled receptor kinase 4 isoform X5

      Conserved Domains (3) summary
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl11395
      Location:373 → 438
      Pkinase_C; Protein kinase C terminal domain
      cl21453
      Location:185 → 393
      PKc_like; Protein Kinases, catalytic domain

    6. XM_036164796.1 → XP_036020689.1  G protein-coupled receptor kinase 4 isoform X1

      Conserved Domains (2) summary
      cd05605
      Location:185 → 469
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    7. XM_030254136.2 → XP_030109996.1  G protein-coupled receptor kinase 4 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    8. XM_036164801.1 → XP_036020694.1  G protein-coupled receptor kinase 4 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    9. XM_036164797.1 → XP_036020690.1  G protein-coupled receptor kinase 4 isoform X2

      Conserved Domains (2) summary
      cd05605
      Location:146 → 430
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:12 → 144
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    10. XM_030254135.2 → XP_030109995.1  G protein-coupled receptor kinase 4 isoform X3

      Conserved Domains (2) summary
      cd05605
      Location:145 → 429
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:11 → 143
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    11. XM_030254137.2 → XP_030109997.1  G protein-coupled receptor kinase 4 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    12. XM_036164799.1 → XP_036020692.1  G protein-coupled receptor kinase 4 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    13. XM_030254138.1 → XP_030109998.1  G protein-coupled receptor kinase 4 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003955585.2 RNA Sequence

    2. XR_003955583.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70291.2 GenPept UniProtKB/Swiss-Prot:O70291

    Gene LinkOut

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