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    Wdcp WD repeat and coiled coil containing [ Mus musculus (house mouse) ]

    Gene ID: 238037, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wdcpprovided by MGI
    Official Full Name
    WD repeat and coiled coil containingprovided by MGI
    Primary source
    MGI:MGI:3040699
    See related
    Ensembl:ENSMUSG00000051721 AllianceGenome:MGI:3040699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430092C04
    Summary
    Predicted to enable kinase binding activity. Predicted to be involved in protein complex oligomerization. Orthologous to human WDCP (WD repeat and coiled coil containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 2.7), CNS E11.5 (RPKM 2.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A1.1; 12 2.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4892384..4910049)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4842351..4860049)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8478 Neighboring gene splicing factor 3B, subunit 6 Neighboring gene FK506 binding protein 1b Neighboring gene STARR-positive B cell enhancer ABC_E4023 Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene UBX domain protein 2A Neighboring gene STARR-seq mESC enhancer starr_31460

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and coiled-coil-containing protein
    Names
    WD repeat and coiled-coil-containing protein C2orf44 homolog
    WD repeat-containing protein C2orf44 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170858.1 → NP_001164329.1  WD repeat and coiled-coil-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001164329.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      CT571254
      Consensus CDS
      CCDS49019.1
      UniProtKB/Swiss-Prot
      Q3U2S5, Q6NV72, Q8C9V8
      UniProtKB/TrEMBL
      A0A1W2P880
      Related
      ENSMUSP00000151585.2, ENSMUST00000220215.2
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 637
      WDCP; WD repeat and coiled-coil-containing protein family

    2. NM_001422811.1 → NP_001409740.1  WD repeat and coiled-coil-containing protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT571254
      UniProtKB/TrEMBL
      A0A1Y7VJP4

    3. NM_173416.3 → NP_775592.2  WD repeat and coiled-coil-containing protein isoform 2

      See identical proteins and their annotated locations for NP_775592.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 3' coding region and 3' UTR versus variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      CT571254
      Consensus CDS
      CCDS25793.1
      UniProtKB/TrEMBL
      A0A1W2P880
      Related
      ENSMUSP00000054102.5, ENSMUST00000053034.6
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 603
      DUF4613; Domain of unknown function (DUF4613)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4892384..4910049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315049.3 → XP_017170538.1  WD repeat and coiled-coil-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VJP4
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 664
      WDCP; WD repeat and coiled-coil-containing protein family

    2. XM_036157388.1 → XP_036013281.1  WD repeat and coiled-coil-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VJP4
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 664
      WDCP; WD repeat and coiled-coil-containing protein family

    3. XM_036157390.1 → XP_036013283.1  WD repeat and coiled-coil-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A1W2P880
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 601
      WDCP; WD repeat and coiled-coil-containing protein family

    4. XM_036157389.1 → XP_036013282.1  WD repeat and coiled-coil-containing protein isoform X2

      UniProtKB/Swiss-Prot
      Q3U2S5, Q6NV72, Q8C9V8
      UniProtKB/TrEMBL
      A0A1W2P880
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 637
      WDCP; WD repeat and coiled-coil-containing protein family

    5. XM_017315048.3 → XP_017170537.1  WD repeat and coiled-coil-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VJP4
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 664
      WDCP; WD repeat and coiled-coil-containing protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NV72.2 GenPept UniProtKB/Swiss-Prot:Q6NV72

    Gene LinkOut

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