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    Hs3st1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 15476, updated on 26-Mar-2024

    Summary

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    Official Symbol
    Hs3st1provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 1provided by MGI
    Primary source
    MGI:MGI:1201606
    See related
    Ensembl:ENSMUSG00000051022 AllianceGenome:MGI:1201606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3-Ost; Hsg3ost; D5Wsu110e
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; appendicular skeleton; ear; hindlimb; and nervous system. Orthologous to human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 31.6), lung adult (RPKM 23.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 21.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (39771278..39802791, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (39613935..39645592, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 5 pseudogene Neighboring gene RIKEN cDNA 4930513D17 gene Neighboring gene STARR-seq mESC enhancer starr_12937 Neighboring gene predicted gene, 25377 Neighboring gene STARR-seq mESC enhancer starr_12938 Neighboring gene STARR-positive B cell enhancer mm9_chr5:40022129-40022429 Neighboring gene STARR-positive B cell enhancer ABC_E3573 Neighboring gene STARR-seq mESC enhancer starr_12939 Neighboring gene STARR-seq mESC enhancer starr_12940 Neighboring gene STARR-seq mESC enhancer starr_12941 Neighboring gene STARR-seq mESC enhancer starr_12942 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:40352258-40352559 Neighboring gene predicted gene, 35191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation. Ferreras L, et al. Biochim Biophys Acta Gen Subj, 2019 May. PMID 30794825
    2. Histochemical analysis of heparan sulfate 3-O-sulfotransferase expression in mouse brain. Yabe T, et al. Methods Mol Biol, 2015. PMID 25325966
    3. Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. Edavettal SC, et al. J Biol Chem, 2004 Jun 11. PMID 15060080
    4. Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes. Shworak NW, et al. Glycoconj J, 2002 May-Jun. PMID 12975616
    5. Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. HajMohammadi S, et al. J Clin Invest, 2003 Apr. PMID 12671048, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of heparan sulfate sulfotransferases was examined by in situ hybridization.
      Title: Histochemical analysis of heparan sulfate 3-O-sulfotransferase expression in mouse brain.
    2. Crystal structure of the binary complex of 3-OST-1 and PAP provide information essential for understanding the biosynthesis of anticoagulant heparan sulfate and the general mechanism of action of heparan sulfate sulfotransferases.
      Title: Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1.
    3. the 3-OST-1 enzyme produces the majority of tissue anticoagulant heparan sulfate
      Title: Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis.
    4. Hs3st1(-/-) mice do not show an obvious procoagulant phenotype.
      Title: Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes.
    5. In this paper a conformational change is described that occurs in heparan sulfate 3-O-sulfotransferase-1 upon binding to heparan sulfate.
      Title: A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycosaminoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 1
    Names
    heparan sulfate 3-O-sulfotransferase 1
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
    NP_001408509.1
    NP_001408510.1
    NP_034604.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421580.1 → NP_001408509.1  heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC098713
      UniProtKB/Swiss-Prot
      O35310

    2. NM_001421581.1 → NP_001408510.1  heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC098713
      UniProtKB/Swiss-Prot
      O35310

    3. NM_010474.2 → NP_034604.1  heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

      See identical proteins and their annotated locations for NP_034604.1

      Status: VALIDATED

      Source sequence(s)
      AK087753, BY585739, CJ144446
      Consensus CDS
      CCDS19257.1
      UniProtKB/Swiss-Prot
      O35310
      Related
      ENSMUSP00000051055.7, ENSMUST00000053116.7
      Conserved Domains (1) summary
      pfam00685
      Location:58 → 295
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      39771278..39802791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35310.1 GenPept UniProtKB/Swiss-Prot:O35310

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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