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    Atxn7l2 ataxin 7-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 72522, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Atxn7l2provided by MGI
    Official Full Name
    ataxin 7-like 2provided by MGI
    Primary source
    MGI:MGI:1919772
    See related
    Ensembl:ENSMUSG00000048997 AllianceGenome:MGI:1919772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610528J18Rik
    Summary
    Orthologous to human ATXN7L2 (ataxin 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 15.1), whole brain E14.5 (RPKM 13.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.3; 3 46.87 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108109538..108117843, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108202222..108210577, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40122 Neighboring gene adhesion molecule with Ig like domain 1 Neighboring gene cytochrome b-561 domain containing 1 Neighboring gene synaptophysin like 2 Neighboring gene SIVA1, apoptosis-inducing factor pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ataxin-7-like protein 2
    Names
    mFLJ00381 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289545.2 → NP_001276474.1  ataxin-7-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001276474.1

      Status: VALIDATED

      Source sequence(s)
      AL671854
      UniProtKB/TrEMBL
      Q5HZJ2
      Conserved Domains (1) summary
      pfam08313
      Location:258 → 321
      SCA7; SCA7, zinc-binding domain

    2. NM_175183.6 → NP_780392.1  ataxin-7-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_780392.1

      Status: VALIDATED

      Source sequence(s)
      AL671854
      Consensus CDS
      CCDS17754.1
      UniProtKB/TrEMBL
      B7ZMR6, Q5HZJ2, Q8C8K6
      Related
      ENSMUSP00000099693.3, ENSMUST00000102633.9
      Conserved Domains (1) summary
      pfam08313
      Location:200 → 263
      SCA7; SCA7, zinc-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108109538..108117843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502137.4 → XP_006502200.1  ataxin-7-like protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZCC3
      Related
      ENSMUSP00000112976.2, ENSMUST00000117409.8
      Conserved Domains (1) summary
      pfam08313
      Location:226 → 289
      SCA7; zinc-binding domain

    2. XM_006502136.2 → XP_006502199.1  ataxin-7-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q5HZJ2
      Conserved Domains (2) summary
      COG5602
      Location:151 → 354
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam08313
      Location:226 → 289
      SCA7; zinc-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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