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    Gng7 guanine nucleotide binding protein (G protein), gamma 7 [ Mus musculus (house mouse) ]

    Gene ID: 14708, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gng7provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma 7provided by MGI
    Primary source
    MGI:MGI:95787
    See related
    Ensembl:ENSMUSG00000048240 AllianceGenome:MGI:95787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3b
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Involved in regulation of adenylate cyclase activity. Acts upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in central nervous system; early conceptus; oocyte; and retina. Orthologous to human GNG7 (G protein subunit gamma 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 23.8), frontal lobe adult (RPKM 19.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80784463..80850742, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80948624..81014925, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene lamin B2 Neighboring gene STARR-positive B cell enhancer ABC_E721 Neighboring gene growth arrest and DNA-damage-inducible 45 beta Neighboring gene STARR-seq mESC enhancer starr_27304 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene STARR-seq mESC enhancer starr_27308 Neighboring gene STARR-seq mESC enhancer starr_27310 Neighboring gene STARR-positive B cell enhancer ABC_E2951 Neighboring gene STARR-positive B cell enhancer ABC_E1807 Neighboring gene STARR-positive B cell enhancer ABC_E10629 Neighboring gene DIRAS family, GTP-binding RAS-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E2952 Neighboring gene predicted gene 16099 Neighboring gene solute carrier family 39 (zinc transporter), member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Selective Manipulation of G-Protein γ(7) Subunit in Mice Provides New Insights into Striatal Control of Motor Behavior. Brunori G, et al. J Neurosci, 2021 Nov 3. PMID 34544837, Free PMC Article
    2. Age-dependent dystonia in striatal Gγ7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole. Sasaki K, et al. J Neurochem, 2013 Mar. PMID 23311775
    3. Gγ7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety. Halder SK, et al. Biochem Biophys Res Commun, 2020 Jan 29. PMID 31759625
    4. NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice. Sasaki K, et al. Mol Brain, 2015 Dec 4. PMID 26637193, Free PMC Article
    5. Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice. Schwindinger WF, et al. J Biol Chem, 2012 Mar 2. PMID 22207761, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selective Manipulation of G-Protein gamma7 Subunit in Mice Provides New Insights into Striatal Control of Motor Behavior.
      Title: Selective Manipulation of G-Protein γ(7) Subunit in Mice Provides New Insights into Striatal Control of Motor Behavior.
    2. Ggamma7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety.
      Title: Gγ7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety.
    3. Ggamma7 knockout mice exhibit age-dependent deficiency in rotarod behavior and increased dystonia without loss of striatal neurons.
      Title: Age-dependent dystonia in striatal Gγ7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole.
    4. Synergistic roles for G-protein gamma3 and gamma7 subtypes in seizure susceptibility as revealed in double knock-out mice.
      Title: Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice.
    5. A(2A)R G-protein alpha(olf)beta(2)gamma(7) interface as a possible therapeutic target for Parkinson disease.
      Title: Adenosine A2A receptor signaling and golf assembly show a specific requirement for the gamma7 subtype in the striatum.
    6. Loss of this gene protein alters behavior and reduces striatal alpha(olf) level and cAMP production
      Title: Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Names
    guanine nucleotide binding protein (G protein), gamma 7 subunit
    heterotrimeric guanine nucleotide-binding protein 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038655.2 → NP_001033744.2  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

      Status: VALIDATED

      Source sequence(s)
      AC152500
      Consensus CDS
      CCDS24039.1
      UniProtKB/Swiss-Prot
      Q61016, Q8JZP6
      UniProtKB/TrEMBL
      Q3UGN1
      Related
      ENSMUSP00000114003.2, ENSMUST00000118233.8

    2. NM_001406263.1 → NP_001393192.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

      Status: VALIDATED

      Source sequence(s)
      AC152500
      UniProtKB/Swiss-Prot
      Q61016, Q8JZP6
      UniProtKB/TrEMBL
      Q3UGN1

    3. NM_001406264.1 → NP_001393193.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

      Status: VALIDATED

      Source sequence(s)
      AC152500
      UniProtKB/Swiss-Prot
      Q61016, Q8JZP6
      UniProtKB/TrEMBL
      Q3UGN1

    4. NM_010319.4 → NP_034449.3  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

      Status: VALIDATED

      Source sequence(s)
      AC152500
      Consensus CDS
      CCDS24039.1
      UniProtKB/Swiss-Prot
      Q61016, Q8JZP6
      UniProtKB/TrEMBL
      Q3UGN1
      Related
      ENSMUSP00000112409.2, ENSMUST00000117805.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80784463..80850742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61016.2 GenPept UniProtKB/Swiss-Prot:Q61016

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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