U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Pygo2 pygopus 2 [ Mus musculus (house mouse) ]

    Gene ID: 68911, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pygo2provided by MGI
    Official Full Name
    pygopus 2provided by MGI
    Primary source
    MGI:MGI:1916161
    See related
    Ensembl:ENSMUSG00000047824 AllianceGenome:MGI:1916161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190004M21Rik
    Summary
    Enables chromatin binding activity; histone acetyltransferase regulator activity; and histone binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; positive regulation of chromatin binding activity; and spermatid nucleus differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skin. Orthologous to human PYGO2 (pygopus family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 22.5), ovary adult (RPKM 22.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    3 F1; 3 39.12 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89337521..89342438)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89430114..89435131)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08239 Neighboring gene CDC28 protein kinase 1b Neighboring gene src homology 2 domain-containing transforming protein C1 Neighboring gene STARR-positive B cell enhancer ABC_E2080 Neighboring gene STARR-positive B cell enhancer ABC_E9557 Neighboring gene pre B cell leukemia transcription factor interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6071 Neighboring gene STARR-positive B cell enhancer ABC_E2081 Neighboring gene phosphomevalonate kinase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer. Saxena M, et al. Cancer Res, 2020 Sep 1. PMID 32586983
    2. Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development. Narytnyk A, et al. Stem Cell Rev Rep, 2014 Feb. PMID 23955574, Free PMC Article
    3. Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. Gu B, et al. Cell Stem Cell, 2013 Jul 3. PMID 23684539, Free PMC Article
    4. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Li B, et al. Genesis, 2007 May. PMID 17458864
    5. Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway. Li J, et al. Cell Prolif, 2022 Oct. PMID 35707871, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3beta pathway.
      Title: Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway.
    2. A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.
      Title: A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.
    3. Our study revealed an association between Pygo2 function and obesity or diabetes. we showed that Pygo2 exhibited a declined expression pattern during adipocyte differentiation, resulting in an attenuated Wnt/beta-catenin output level. We further showed impaired glucose tolerance and decreased systemic insulin sensitivity in Pygo2-deficient mice.
      Title: Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin-Axin2-GSK3β Signaling Pathway.
    4. Suggest that Pygo2 has a tumor promoting function related to Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression.
      Title: The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
    5. Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
      Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
    6. It analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells.
      Title: Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development.
    7. These findings identify Pygo2 as an important regulator of Wnt/beta-catenin function in skin epithelia and p53 activation as a prominent downstream event of beta-catenin/Pygo2 action in stem cell activation.
      Title: Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.
    8. these results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 mice.
      Title: Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.
    9. even in the absence of the potentially redundant Pygo1, Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development
      Title: The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.
    10. Pygo2 converges with Wnt/beta-catenin signaling on progenitor cell regulation and cell cycle gene expression.
      Title: Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within anatomical structure development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within kidney development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatid nucleus differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid nucleus differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pygopus homolog 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293763.2 → NP_001280692.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001280692.1

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (2) summary
      PRK14959
      Location:135 → 271
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      cd15636
      Location:291 → 344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

    2. NM_001293766.3 → NP_001280695.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001280695.1

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (2) summary
      PRK14959
      Location:135 → 271
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      cd15636
      Location:291 → 344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

    3. NM_001293767.2 → NP_001280696.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001280696.1

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (2) summary
      PRK14959
      Location:135 → 271
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      cd15636
      Location:291 → 344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

    4. NM_001293768.2 → NP_001280697.1  pygopus homolog 2 isoform a

      See identical proteins and their annotated locations for NP_001280697.1

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS79952.1
      UniProtKB/TrEMBL
      Q80V76
      Related
      ENSMUSP00000053672.5, ENSMUST00000060061.11
      Conserved Domains (1) summary
      cd15636
      Location:328 → 381
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

    5. NM_001429109.1 → NP_001416038.1  pygopus homolog 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC171273

    6. NM_001429110.1 → NP_001416039.1  pygopus homolog 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC171273

    7. NM_026869.3 → NP_081145.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_081145.1

      Status: VALIDATED

      Source sequence(s)
      AI843615, AK132759
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Related
      ENSMUSP00000103036.2, ENSMUST00000107413.2
      Conserved Domains (2) summary
      PRK14959
      Location:135 → 271
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      cd15636
      Location:291 → 344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89337521..89342438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252785.1 → XP_030108645.1  pygopus homolog 2 isoform X1

      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (2) summary
      PRK14959
      Location:135 → 271
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      cd15636
      Location:291 → 344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

    2. XM_030252784.2 → XP_030108644.1  pygopus homolog 2 isoform X1

      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (2) summary
      PRK14959
      Location:135 → 271
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      cd15636
      Location:291 → 344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous