Slc26a1 solute carrier family 26 (sulfate transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc26a1provided by MGI
Official Full Name: solute carrier family 26 (sulfate transporter), member 1provided by MGI
Primary source: MGI:MGI:2385894
See related: Ensembl:ENSMUSG00000046959 AllianceGenome:MGI:2385894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sat1
Summary: Enables anion transmembrane transporter activity. Involved in chloride transport. Acts upstream of or within oxalate transport and sulfate transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; integumental system; liver; nose; and urinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 59.7), kidney adult (RPKM 58.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.24 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (108817744..108826246, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (108669878..108678380, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc26a1 is not essential for spermatogenesis and male fertility in mice.
Title: Slc26a1 is not essential for spermatogenesis and male fertility in mice.
that SAT-1 has a major role in oxalate excretion via the intestine
Title: Absence of the sulfate transporter SAT-1 has no impact on oxalate handling by mouse intestine and does not cause hyperoxaluria or hyperoxalemia.
Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
Title: SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
study concludes that a DIDS-sensitive basolateral transporter is involved in mediating oxalate secretion across mouse duodenum, but Sat1 itself is dispensable for this process
Title: Sat1 is dispensable for active oxalate secretion in mouse duodenum.
Sat1 regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity.
Title: Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice.
first characterization of the structure and regulation of the Sat1 gene encoding a SO(4)(2-)/chloride/oxalate anion transporter
Title: The mouse sulfate anion transporter gene Sat1 (Slc26a1): cloning, tissue distribution, gene structure, functional characterization, and transcriptional regulation thyroid hormone.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc26a1 (e-PCR), detects polymorphism
- UniSTS:547062

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfate:bicarbonate antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sulfate:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carboxylic acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxalate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxalate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sulfate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sulfate anion transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310691.1 → NP_001297620.1 sulfate anion transporter 1 isoform 1

See identical proteins and their annotated locations for NP_001297620.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC161813

Consensus CDS

CCDS80355.1

UniProtKB/TrEMBL

G5E8U1, Q8R4W9

Related

ENSMUSP00000113185.2, ENSMUST00000119270.2

Conserved Domains (2) summary

cd07042
Location:554 → 686

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:71 → 702

sulP; high affinity sulphate transporter 1
NM_001310692.1 → NP_001297621.1 sulfate anion transporter 1 isoform 2

See identical proteins and their annotated locations for NP_001297621.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks a segment in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC161813

Consensus CDS

CCDS19517.1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Related

ENSMUSP00000131282.2, ENSMUST00000163328.8

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
NM_174870.4 → NP_777359.3 sulfate anion transporter 1 isoform 2

See identical proteins and their annotated locations for NP_777359.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC161813, AK143528

Consensus CDS

CCDS19517.1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Related

ENSMUSP00000051561.8, ENSMUST00000051757.14

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

108817744..108826246 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254412.1 → XP_030110272.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
XM_017320856.2 → XP_017176345.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
XM_036165081.1 → XP_036020974.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
XM_030254414.1 → XP_030110274.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
XM_030254411.1 → XP_030110271.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
XM_017320855.2 → XP_017176344.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
XM_030254413.2 → XP_030110273.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1
XM_036165082.1 → XP_036020975.1 sulfate anion transporter 1 isoform X1

UniProtKB/Swiss-Prot

P58735, Q80WF6

UniProtKB/TrEMBL

Q3UPH6, Q8R4W9

Conserved Domains (1) summary

TIGR00815
Location:55 → 686

sulP; high affinity sulphate transporter 1