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    Lrit2 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 239038, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrit2provided by MGI
    Official Full Name
    leucine-rich repeat, immunoglobulin-like and transmembrane domains 2provided by MGI
    Primary source
    MGI:MGI:2444885
    See related
    Ensembl:ENSMUSG00000043418 AllianceGenome:MGI:2444885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrrc22; A930010E21Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in cerebellum; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human LRIT2 (leucine rich repeat, Ig-like and transmembrane domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward liver adult (RPKM 1.3) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 B; 14 21.29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (36784923..36795700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (37064433..37073743)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36416 Neighboring gene coiled-coil serine rich 2 Neighboring gene predicted gene, 53853 Neighboring gene STARR-seq mESC enhancer starr_36418 Neighboring gene STARR-positive B cell enhancer ABC_E8553 Neighboring gene STARR-seq mESC enhancer starr_36421 Neighboring gene retinal G protein coupled receptor Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 Neighboring gene cadherin-related family member 1 Neighboring gene G protein coupled receptor 15 ligand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity. Ueno A, et al. Cell Rep, 2018 Mar 27. PMID 29590622
    2. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
    3. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lrit2 is dispensable for photoreceptor synapse formation
      Title: Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
    Names
    leucine-rich repeat-containing protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360134.2 → NP_001347063.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158525
      Conserved Domains (5) summary
      sd00031
      Location:16 → 39
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:63 → 122
      LRR_8; Leucine rich repeat
      pfam13927
      Location:212 → 290
      Ig_3; Immunoglobulin domain
      cl15307
      Location:159 → 202
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21522
      Location:326 → 397
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_173418.5 → NP_775594.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_775594.1

      Status: VALIDATED

      Source sequence(s)
      AC158525
      Consensus CDS
      CCDS26951.1
      UniProtKB/Swiss-Prot
      Q6PFC5
      Related
      ENSMUSP00000056642.4, ENSMUST00000057176.5
      Conserved Domains (7) summary
      pfam07679
      Location:253 → 344
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:57 → 80
      LRR_1; leucine-rich repeat [structural motif]
      pfam00041
      Location:367 → 441
      fn3; Fibronectin type III domain
      pfam12799
      Location:80 → 119
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:103 → 163
      LRR_8; Leucine rich repeat
      cl11960
      Location:266 → 345
      Ig; Immunoglobulin domain
      cl15307
      Location:200 → 243
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      36784923..36795700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247791.2 → XP_030103651.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform X1

      Conserved Domains (5) summary
      sd00031
      Location:16 → 39
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:63 → 122
      LRR_8; Leucine rich repeat
      pfam13927
      Location:212 → 290
      Ig_3; Immunoglobulin domain
      cl15307
      Location:159 → 202
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21522
      Location:326 → 397
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_030247792.1 → XP_030103652.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      pfam13927
      Location:61 → 139
      Ig_3; Immunoglobulin domain
      cl15307
      Location:8 → 51
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21522
      Location:175 → 246
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFC5.1 GenPept UniProtKB/Swiss-Prot:Q6PFC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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