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    Krtcap2 keratinocyte associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 66059, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Krtcap2provided by MGI
    Official Full Name
    keratinocyte associated protein 2provided by MGI
    Primary source
    MGI:MGI:1913309
    See related
    Ensembl:ENSMUSG00000042747 AllianceGenome:MGI:1913309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kcp2; 0610010I12Rik
    Summary
    Predicted to enable enzyme activator activity. Predicted to be involved in protein N-linked glycosylation via arginine. Part of oligosaccharyltransferase complex. Is expressed in central nervous system; embryo; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human KRTCAP2 (keratinocyte associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 171.0), duodenum adult (RPKM 136.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krtcap2 in Genome Data Viewer
    Location:
    3 F1; 3 39.03 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89153201..89157036)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89245904..89249729)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11198 Neighboring gene microRNA 92b Neighboring gene mucin 1, transmembrane Neighboring gene tripartite motif-containing 46 Neighboring gene STARR-positive B cell enhancer ABC_E4552 Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 3 Neighboring gene solute carrier family 50 (sugar transporter), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP). Wilson CM, et al. J Biol Chem, 2011 Sep 9. PMID 21768116, Free PMC Article
    2. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article
    3. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Shibatani T, et al. Biochemistry, 2005 Apr 26. PMID 15835887
    4. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. components of the oligosaccharyltransferase complex DC2 and KCP2 can interact with the gamma-secretase and affect the amyloid precursor protein processing pathway.
      Title: DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via arginine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via arginine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratinocyte-associated protein 2
    Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2
    oligosaccharyl transferase subunit KCP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310625.1 → NP_001297554.1  keratinocyte-associated protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001297554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA032745, AC132327, AW495353
      Consensus CDS
      CCDS79949.1
      UniProtKB/TrEMBL
      A0A0A0MQN1
      Conserved Domains (1) summary
      pfam09775
      Location:1 → 109
      Keratin_assoc; Keratinocyte-associated protein 2

    2. NM_025327.3 → NP_079603.1  keratinocyte-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_079603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002479, AW495353
      Consensus CDS
      CCDS50960.1
      UniProtKB/Swiss-Prot
      Q5RL79, Q9CQK5
      Related
      ENSMUSP00000043540.7, ENSMUST00000040888.12
      Conserved Domains (1) summary
      pfam09775
      Location:3 → 131
      Keratin_assoc; Keratinocyte-associated protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89153201..89157036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252748.2 → XP_030108608.1  keratinocyte-associated protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q5RL79, Q9CQK5
      Conserved Domains (1) summary
      pfam09775
      Location:3 → 131
      Keratin_assoc; Keratinocyte-associated protein 2

    2. XM_006501870.5 → XP_006501933.3  keratinocyte-associated protein 2 isoform X1

      Conserved Domains (1) summary
      pfam09775
      Location:86 → 214
      Keratin_assoc; Keratinocyte-associated protein 2

    3. XM_030252749.2 → XP_030108609.1  keratinocyte-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MQN1
      Related
      ENSMUSP00000130372.3, ENSMUST00000168900.3
      Conserved Domains (1) summary
      pfam09775
      Location:1 → 109
      Keratin_assoc; Keratinocyte-associated protein 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RL79.2 GenPept UniProtKB/Swiss-Prot:Q5RL79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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