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    Acot5 acyl-CoA thioesterase 5 [ Mus musculus (house mouse) ]

    Gene ID: 217698, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Acot5provided by MGI
    Official Full Name
    acyl-CoA thioesterase 5provided by MGI
    Primary source
    MGI:MGI:2384969
    See related
    Ensembl:ENSMUSG00000042540 AllianceGenome:MGI:2384969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTE-Ic
    Summary
    Enables acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; monocarboxylic acid metabolic process; and saturated monocarboxylic acid metabolic process. Located in cytosol and peroxisome. Orthologous to human ACOT1 (acyl-CoA thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 10.1), kidney adult (RPKM 7.8) and 26 other tissues See more
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    Genomic context

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    Location:
    12 D1; 12 39.03 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84115908..84122798)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84069077..84076024)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40474 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 3 Neighboring gene acyl-CoA thioesterase 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32724 Neighboring gene acyl-CoA thioesterase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhancement of free fatty acid production in Saccharomyces cerevisiae by control of fatty acyl-CoA metabolism. Chen L, et al. Appl Microbiol Biotechnol, 2014 Aug. PMID 24769906
    2. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. Westin MA, et al. J Biol Chem, 2004 May 21. PMID 15007068
    3. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. Hunt MC, et al. J Lipid Res, 2005 Sep. PMID 16103133
    4. Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. Lee J, et al. Mol Cell Proteomics, 2007 Apr. PMID 17208939, Free PMC Article
    5. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in saturated monocarboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in unsaturated monocarboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase 5
    Names
    peroxisomal acyl-CoA thioesterase Ic
    peroxisomal acyl-coenzyme A thioester hydrolase Ic
    NP_001334346.1
    NP_663419.3
    XP_006515756.4
    XP_011242377.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347417.1 → NP_001334346.1  acyl-coenzyme A thioesterase 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125071
      Consensus CDS
      CCDS83986.1
      UniProtKB/TrEMBL
      Q91YQ6
      Related
      ENSMUSP00000072322.5, ENSMUST00000072505.5

    2. NM_145444.3 → NP_663419.3  acyl-coenzyme A thioesterase 5 isoform 1

      See identical proteins and their annotated locations for NP_663419.3

      Status: VALIDATED

      Source sequence(s)
      AC125071
      Consensus CDS
      CCDS26037.1
      UniProtKB/Swiss-Prot
      E9QKJ5, Q6Q2Z6
      Related
      ENSMUSP00000042019.5, ENSMUST00000046422.11
      Conserved Domains (3) summary
      pfam04775
      Location:16 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:204 → 412
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      cl21494
      Location:145 → 259
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84115908..84122798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515693.5 → XP_006515756.4  acyl-coenzyme A thioesterase 5 isoform X1

      UniProtKB/Swiss-Prot
      E9QKJ5, Q6Q2Z6
      Conserved Domains (3) summary
      pfam04775
      Location:16 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:204 → 412
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      cl21494
      Location:145 → 259
      Abhydrolase; alpha/beta hydrolases

    2. XM_011244075.4 → XP_011242377.1  acyl-coenzyme A thioesterase 5 isoform X2

      Conserved Domains (2) summary
      pfam04775
      Location:16 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:204 → 221
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q2Z6.2 GenPept UniProtKB/Swiss-Prot:Q6Q2Z6

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