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    Gtpbp1 GTP binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 14904, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gtpbp1provided by MGI
    Official Full Name
    GTP binding protein 1provided by MGI
    Primary source
    MGI:MGI:109443
    See related
    Ensembl:ENSMUSG00000042535 AllianceGenome:MGI:109443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GP-1; Gtpbp
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in GTP metabolic process; positive regulation of mRNA catabolic process; and translational elongation. Predicted to be located in cytosol. Predicted to be part of cytoplasmic exosome (RNase complex). Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human GTPBP1 (GTP binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.9), spleen adult (RPKM 20.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 37.85 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79574202..79605680)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79690001..79721479)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E389 Neighboring gene Sad1 and UNC84 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7390 Neighboring gene predicted gene 16576

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunocytochemical analyses and targeted gene disruption of GTPBP1. Senju S, et al. Mol Cell Biol, 2000 Sep. PMID 10938096, Free PMC Article
    2. Identification of human and mouse GP-1, a putative member of a novel G-protein family. Senju S, et al. Biochem Biophys Res Commun, 1997 Feb 13. PMID 9070279
    3. Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling. Liu DC, et al. eNeuro, 2020 Mar/Apr. PMID 32161037, Free PMC Article
    4. Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family. Watanabe M, et al. Gene, 2000 Oct 3. PMID 11054535
    5. GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis. Terrey M, et al. Elife, 2020 Nov 13. PMID 33186095, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling.
      Title: Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-aminoacyl-tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein 1
    Names
    G-protein 1
    GP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013818.2 → NP_038846.2  GTP-binding protein 1

      See identical proteins and their annotated locations for NP_038846.2

      Status: VALIDATED

      Source sequence(s)
      BC046228
      Consensus CDS
      CCDS27648.1
      UniProtKB/Swiss-Prot
      O08582, Q3UD96, Q3UGW6, Q545R1, Q80ZY5
      Related
      ENSMUSP00000043575.9, ENSMUST00000046463.10
      Conserved Domains (4) summary
      cd04165
      Location:162 → 386
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:48 → 574
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:395 → 481
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:487 → 573
      GTPBP_III; Domain III of the GP-1 family of GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79574202..79605680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520450.2 → XP_006520513.1  GTP-binding protein 1 isoform X2

      Conserved Domains (2) summary
      cd04165
      Location:50 → 274
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:1 → 462
      GTPBP1; GTPase [General function prediction only]

    2. XM_036159161.1 → XP_036015054.1  GTP-binding protein 1 isoform X1

      Conserved Domains (2) summary
      cd04165
      Location:81 → 305
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:1 → 493
      GTPBP1; GTPase [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08582.2 GenPept UniProtKB/Swiss-Prot:O08582

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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